EDWARD W MERRILL
Engineering in Belmont, MA

6616982, Sep 9, 2003

Nov 26, 2002

10/305915

Edward W. Merrill - Belmont MA
Susan S. Allgor - Arlington MA
Gladys C. Leung - Highlands Ranch CO

Massachusetts Institute of Technology - Cambridge MA

C08F 246

427496, 427164, 427331, 427333, 4273855, 4274071

Methods are provided for the fabrication of hydrophilic coatings on hydrophobic surfaces. In one embodiment, a polyethylene oxide (PEO) coating is fabricated on the surface of a polymeric material by contacting the surface with a methacrylic acid or acrylic acid monomer. The monomer first is reacted, for example by irradiation with an electron beam, to polymerize and covalently attach the monomer to the surface, to improve the hydrophilicity of the polymeric material. A coating of PEO molecules is subsequently attached to the polymer surface by hydrogen bond complexation. The PEO coating then may be covalently grafted onto the surface, for example, by irradiation grafting with an electron beam. The covalent grafting of a coating of the methacrylic or acrylic monomers to the surface greatly improves the wettability of the surface, and facilitates the covalent or non-covalent attachment of a coating of PEO to the polymer surface. Thus, hydrophilic PEO coatings can be fabricated on hydrophobic polymer surfaces, to improve the biocompatibility and other properties of the polymer surfaces.

6786933, Sep 7, 2004

Apr 26, 2001

09/842166

Edward W. Merrill - Belmont MA
William H. Harris - Belmont MA
Murali Jasty - Weston MA
Orhun Muratoglu - Cambridge MA
Charles R. Bragdon - Weymouth MA
Daniel O. OConnor - East Taunton MA
Premnath Venugopalan - Chennai, IN

The General Hospital Corporation - Boston MA
Massachusetts Institute of Technology - Cambridge MA

A61F 232

623 2358, 623 2211, 623 2221, 623 1811

A medical prosthesis for use within a body which is formed of radiation treated ultra high molecular weight polyethylene having substantially no detectable free radial. Preferred prosthesis exhibits reduced production of particles from the prosthesis during wear of the prosthesis, and are substantially oxidation resistant. Methods of manufacturing wear resistant medical prosthesis and materials used therein are also provided.

6641617, Nov 4, 2003

Dec 3, 1999

09/454123

Edward W. Merrill - Belmont MA
William H. Harris - Belmont MA
Murali Jasty - Weston MA
Orhun Muratoglu - Cambridge MA
Charles R. Bragdon - Weymouth MA
Daniel O. OConnor - East Taunton MA
Premnath Venugopalan - Cambridge MA

The General Hospital Corp. - Boston MA
Massachusetts Institute of Technology - Cambridge MA

A61F 232

623 2358, 623 2221

A medical prosthesis for use within the body which is formed of radiation treated ultra high molecular weight polyethylene having substantially no detectable free radicals, is described. Preferred prostheses exhibit reduced production of particles from the prosthesis during wear of the prosthesis, and are substantially oxidation resistant. Methods of manufacture of such devices and material used therein are also provided.

5836313, Nov 17, 1998

Apr 14, 1995

8/422149

Edward Perez - Cambridge MA
David Miller - Brookline MA
Edward W. Merrill - Belmont MA

Massachusetts Institute of Technology - Cambridge MA

A61B 1900, A61F 214

128898

Methods for forming implantable composite keratoprostheses are provided. The methods provide keratoprostheses designed to provide a suitable substrate for corneal epithelial cell growth while maintaining the desirable characteristics of hydrogels, i. e. , clarity, flexibility and the ability to allow diffusive flow of nutrients. In a preferred embodiment the method includes placing corneal tissue in a mold having a corneal implant shape and crosslinking a polymeric solution to chemically bond a biocompatible hydrogel having a thickness between approximately 50 and 100 microns to the corneal tissue to form the keratoprosthesis. Upon implantation, the corneal tissue abuts epithelial cells surrounding the keratoprosthesis. In another preferred embodiment, a polymer solution is placed between the corneal tissue and a pre-formed hydrogel and then polymerized so that the polymer solution couples to both the hydrogel and the corneal tissue.

5906828, May 25, 1999

Oct 8, 1997

8/947063

Linda G. Cima - Lexington MA
Edward W. Merrill - Belmont MA
Philip R. Kuhl - Arlington MA

Massachusetts Institute of Technology - Cambridge MA

A61K 3818, A61K 4730, C12Q 102, C12N 1108

424423

Disclosed are compositions with tethered growth effector molecules, and methods of using these compositions for growing cells and tissues. Growth effector molecules, including growth factors and extracellular matrix molecules, are flexibly tethered to a solid substrate. The compositions can be used either in vitro or in vivo to grow cells and tissues. By tethering the growth factors, they will not diffuse away from the desired location. By making the attachment flexible, the growth effector molecules can more naturally bind to cell surface receptors. A significant feature of these compositions and methods is that they enhance the biological response to the growth factors. The new method also offers other advantages over the traditional methods, in which growth factors are delivered in soluble form: (1) the growth factor is localized to a desired target cell population; (2) significantly less growth factor is needed to exert a biologic response. This method can be used for enhancing the therapeutic use of growth factors in vivo and creating surfaces which will enhance in vitro growth of difficult-to-grow cells such as liver cells.

5171264, Dec 15, 1992

Feb 28, 1990

7/486153

Edward W. Merrill - Belmont MA

Massachusetts Institute of Technology - Cambridge MA

A61M 110

623 3

This invention pertains to a method for immobilizing polyethylene oxide (PEO) star molecules in the form of hydrogels. the PEO star molecules are biocompatible and demonstrate non-thrombogenic properties. As such, the PEO star molecules have numerous uses for biomedical applications. The hydrogels contain a high percentage of terminal hydroxyl groups for attachment of affinity ligands and can be used for separating and purifying therapeutic proteins.

2003011, Jun 26, 2003

Jul 18, 2002

10/197209

Edward Merrill - Belmont MA, US
William Harris - Belmont MA, US
Murali Jasty - Weston MA, US
Orhun Muratoglu - Cambridge MA, US
Charles Bragdon - Weymouth MA, US
Daniel O'Connor - East Taunton MA, US
Premnath Venugopalan - Cambridge MA, US

C08J003/28

522/150000

A medical prosthesis for use within the body which is formed of radiation treated ultra high molecular weight polyethylene having substantially no detectable free radicals, is described. Preferred prostheses exhibit reduced production of particles from the prosthesis during wear of the prosthesis, and are substantially oxidation resistant. Methods of manufacture of such devices and material used therein are also provided.

4906465, Mar 6, 1990

Mar 16, 1988

7/168673

Elliot L. Chaikof - Newton MA
Cynthia Sung - Cambridge MA
Edward W. Merrill - Belmont MA

Massachusetts Institute of Technology - Cambridge MA

A61K 3174, C08G 7704, A61M 3500

424 78

A crosslinked polymer network comprising the reaction product of a polyethylene oxide and a polyglycidoxypropylsiloxane is described. These materials demonstrate low in vivo platelet retention as well as a low thrombogenicity. As such, they can provide antithrombogenic properties to blood contacting devices such as catheters, artificial hearts, ventricular grafts and cardiovascular suture.

2003010, Jun 5, 2003

Jul 18, 2002

10/197263

Edward Merrill - Belmont MA, US
William Harris - Belmont MA, US
Murali Jasty - Weston MA, US
Orhun Muratoglu - Cambridge MA, US
Charles Bragdon - Weymouth MA, US
Daniel O'Connor - East Taunton MA, US
Premnath Venugopalan - Chennai, IN

C08J003/28

522/150000

A medical prosthesis for use within the body which is formed of radiation treated ultra high molecular weight polyethylene having substantially no detectable free radicals, is described. Preferred prostheses exhibit reduced production of particles from the prosthesis during wear of the prosthesis, and are substantially oxidation resistant. Methods of manufacture of such devices and material used therein are also provided.

2012006, Mar 15, 2012

Nov 14, 2011

13/295642

Edward W. Merrill - Belmont MA, US
William H. Harris - Belmont MA, US
Murali Jasty - Weston MA, US
Orhun Muratoglu - Cambridge MA, US
Charles R. Bragdon - Weymouth MA, US
Daniel O. O'Connor - East Taunton MA, US
Premnath Venugopalan - Cambridge MA, US

Massachusetts Institute of Technology - Cambridge MA
The General Hospital Corporation - Boston MA

A61B 19/00, B32B 27/00, C08J 3/28, B32B 15/04, B29C 71/04, A61L 27/16

128898, 264488, 526352, 522161, 428461, 428500

A medical prosthesis for use within the body which is formed of radiation treated ultra high molecular weight polyethylene having substantially no detectable free radicals, is described. Preferred prostheses exhibit reduced production of particles from the prosthesis during wear of the prosthesis, and are substantially oxidation resistant. Methods of manufacture of such devices and material used therein are also provided.