Inventors:
Amir Pelleg - Haverford PA
Edward S. Schulman - Philadelphia PA
Assignee:
Duska Scientific Co. - Haverford PA
International Classification:
A61K 3170
US Classification:
514 47, 514 48, 5142631, 435 72, 435 4
Abstract:
Human mast cell activation is modulated by ATP binding to P2-purinoceptors on the mast cell surface. ATP binding to the purinoceptors provides a target for therapeutic intervention for the treatment of disorders characterized by undesireable mast cell mediator release, such as asthma and allergy. Inhibitors of ATP binding to mast cell P2-purinoceptors are useful therapeutic agents for treatments of those disorders. Methods of treatment using agents, and in vitro screening assays for selection of the therapeutic agents, are described.