Inventors:
Edward S. Neiss - New Canaan CT
Rohit M. Desai - Millwood NY
Raymond D. Youssefyeh - Tarrytown NY
Assignee:
USV Pharmaceutical Corp. - Fort Washington PA
International Classification:
C07D21514, C07D21520
Abstract:
This invention relates to novel lipoxygenase inhibitors possessing anti-inflammatory and anti-allergic activities. The present new compounds are di- and tetra-hydroquinoline or di- and tetra-hydronapthalene derivatives, more particularly, 1,2-, 1,4-, 5,6-, or 7,8-dihydro; 1,2,3,4-tetrahydro-; 5,8-dihydro-; or 5,6,7,8-tetrahydroquinoline or napthalene derivatives of a compound of the formula: ##STR1## and oxides, quaternary ammonium salts and acid salts thereof; wherein A is CH or N;
Z is an alkylene chain containing up to 10 carbon atoms in the principal chain and a total of up to 12 carbon atoms and the said alkylene chain may be attached to the phenyl group through an oxygen atom;
R is the substituent OR. sub. 6 attached to one of the carbon atoms of Z in which R. sub. 6 is H, lower alkyl or phenyl;
X is --O(CHR. sub. 5). sub.