Inventors:
Ronald W. Wood - Rochester NY, US
Jay Reeder - East Rochester NY, US
Edward M. Schwarz - Rochester NY, US
Edward M. Messing - Rochester NY, US
Susan R. Schoen - Macedon NY, US
Margaret A. Vizzard - South Burlington VT, US
Ian Dickerson - Pittsford NY, US
Assignee:
University of Vermont and State Agricultural College - Burlington VT
UNIVERSITY OF ROCHESTER - Rochester NY
International Classification:
A61K 38/02, A61P 29/00, A61K 31/517, G01N 33/566, A61K 31/426
US Classification:
514 183, 435 792, 436501, 514369, 51425217
Abstract:
Diagnostic assessment and therapeutic treatment of pelvic pain disorders, including bladder disorders, bowel disorders, and/or reproductive tissue or organ disorders that are characterized by increased expression of the neuropeptides CGRP and/or PACAP. Additionally, applicants have developed a transgenic non-human model for pelvic pain disorders, where the transgenic animal expresses in bladder sensory neurons a recombinant neuropeptide implicated in the pelvic pain disorder.