Edward Larry Mccleary
Physician at Alpine Vw Dr, Incline Village, NV

8202512, Jun 19, 2012

Aug 4, 2011

13/198289

Edward Larry McCleary - Incline Village NV, US

A61K 47/06, A61K 38/43, A61K 127/00, A61K 9/50, A61K 65/00

424 7802, 424502, 424729, 424745, 424 941

A combination of chemical agents reduces reductive stress by limiting the accumulation of high-energy electrons potentially available to the electron transport chain. A method of metabolic uncoupling therapy comprises: analyzing a specific physiologic process involving reductive stress; identifying a plurality of MUT agents that modulate metabolic pathways by influencing electron flux; and formulating a combination of MUT agents that limits the accumulation of high-energy electrons potentially available to the electron transport chain.

2005012, Jun 16, 2005

Nov 12, 2004

10/986924

Edward McCleary - Incline Village NV, US
Carl Forest - Boulder CO, US
Christine McCleary - Incline Village NV, US

A61K035/78, A61K033/26, A61K031/56, A61K031/522, A61K031/51

424646000, 424733000, 424741000, 424769000, 424771000, 424777000, 424764000, 514548000, 514356000, 514285000, 514291000, 514276000, 514263310, 514350000, 514171000, 514561000, 514567000, 514553000

A composition and method for therapeutic treatment of undesirable neurophysiologic conditions, such as those associated with menopause, the peri-menstrual period, mental conditions such as mood disorders, hyperactivity, impulsiveness, difficulty concentrating, chronic pain conditions, and including neurodegenerative disorders such as age-associated or acoustic-related hearing loss, central, peripheral or autonomic neuropathies and for maintenance of neurophysiologic health, the composition comprising an effective amount of: three agents selected from the group consisting of vinpocetine, huperzine A, magnesium, theanine, pyro-glutamic acid, dextromethorphan, and Vitex agnus-castus fruit; one agent selected from the group consisting of thiamin, niacin, pyridoxine, vanadium, and acetaminophen; and three agents selected from the group consisting of valerian spp, passiflora spp, magnolia spp, scutellaria spp, taurine, melatonin, GABA and black cohosh. The composition may also include an effective amount of an agent selected from the group consisting of white willow bark, dehydroepiandrosterone (DHEA), pregnenolone, ketone bodies, 5-hydroxytryptophan (5-HTP) and a racemic mixture of D,L phenylalanine (DLPA). The method comprises administering the above composition to a human for a therapeutically effective period. The composition may also be combined with a food, beverage, condiment, spice or salad dressing base to provide a food, beverage, condiment, spice or salad dressing product designed to overcome or prevent undesirable conditions frequently associated with menopause, chronic pain or neurophysiologic degeneration.

2005000, Jan 6, 2005

Jul 12, 2004

10/890067

Edward McCleary - Incline Village NV, US
Carl Forest - Boulder CO, US
Christine McCleary - Incline Village NV, US

A61K031/473, A61K031/385, A61K031/198, A61K047/00

424439000, 514295000, 514440000, 514561000

A food, beverage, condiment, spice or salad dressing designed to enhance the human metabolism includes a food, beverage, condiment, spice, or salad dressing base and a weight loss supplement, brain and nerve function enhancement supplement, cholesterol blocker supplement and cholesterol level improvement supplement, liver enhancement supplement, cardiac supplement, vascular supplement, anti-aging supplement, bone supplement, prostrate health enhancement supplement, joint health supplement, fetus developmental (prenatal) and/or a postnatal breast milk enhancement supplement, eye health enhancement supplement, or enhanced physical performance supplement. The supplement is present in an amount in excess of the amount naturally present in the food, beverage, condiment, spice or salad dressing base.

2005009, May 5, 2005

Nov 12, 2004

10/987108

Edward McCleary - Incline Village NV, US
Carl Forest - Boulder CO, US
Christine McCleary - Incline Village NV, US

A61K038/43, A61K031/555, A61K031/4415, A61K031/4188, A61K031/198

424094100, 514383000, 514554000, 514561000, 514574000, 514350000, 514184000, 514400000, 514423000, 514560000, 424762000, 424776000, 514263310, 514171000, 514419000

An orally or parenterally administered composition for reducing the storage of lipids in a human, the composition comprising: an effective amount of hydroxycitric acid; an effective amount of carnitine; an effective amount of biotin; an effective amount of one or more gluconeogenic substrates selected from the group consisting of: aspartate, lactate, glycerol, and a gluconeogenic amino acid or alphaketo analogue thereof; an effective amount of eicosapentanoic acid; and an effective amount of one or more ingredients selected from the group consisting of: medium chain triglycerides (MCT) with fatty acid backbones containing 6 to 14 carbon atoms or their individual fatty acid analogues or metabolic precursors, sesame seeds or derivative products, sesamin and/or its epimer episesamin, caffeine, forskolin, 7-keto dehydroepiandrosterone (7-keto DHEA), green tea extract containing epigallocatechingallate (EGCG), capsaicum, and 5-hydroxytryptophan (5-HTP). The supplement may also be combined with a food, beverage, condiment, spice or salad dressing base to provide a food, beverage, condiment, spice or salad dressing product designed to reduce lipid storage.

2005018, Aug 18, 2005

Mar 23, 2005

11/088388

Edward McCleary - Incline Village NV, US

A61K035/78, A61K033/00, A61K033/10, A61K031/7048, A61K031/353

424686000, 424756000, 424745000, 424717000, 514557000, 514574000, 514027000, 514456000, 424729000, 514733000

Improved nutraceutical compositions and methods for maintaining healthy calcium metabolism and maintenance of muscle mass. The compositions include a first component selected from the group consisting of a citrate anion, a bicarbonate anion and an acetate anion; a second component selected from the group consisting of a potassium cation, a magnesium cation, a calcium cation, and a sodium cation; and a third component selected from the group consisting of resveratrol, green tea extract, tumeric, basil, sage, thyme, ginger or ginger extract, oregano or oregano extract, rosemary or rosemary extract, hypericum perforatum, glycyrrhiza glabra, plantago lanceolata, quercetin, glycyrrhiza glabra, and gingko biloba. The compositions may be administered conventionally in tablets or capsules, as a dietary supplement, or be delivered in a food additive, food or beverage product, functional food, medical food, botanical drug, over-the-counter (OTC) drug, or any other category of product for human or animal consumption.

2006001, Jan 19, 2006

Sep 9, 2005

11/223719

Edward McCleary - Incline Village NV, US

A61K 38/43, A61K 31/4745, A61K 31/385, A61K 31/185, A61K 36/16

514283000, 514440000, 514350000, 514553000, 424094100, 424752000, 514561000, 514565000, 514733000, 514763000

A mental agility composition is composed of at least one agent which promotes synthesis of ATP and/or creatine phosphate in the body; at least one antioxidant for scavenging free radicals in at least one pathway in the body; at least one agent for normalizing or maintaining membrane function and structure in the body; at least one agent for normalizing or maintaining normal neurotransmitter function in the body; at least one agent for down-regulating cortisol action; and at least one agent for suppressing activation of apoptotic pathways in the body. The composition may further contain one or more of at least one agent for suppressing inflammation in the body; at least one agent for normalizing or maintaining vascular wall function and structure in the body; at least one agent for normalizing or maintaining function of nerve growth factors and/or neurotropic factors in the body; at least one agent for suppressing toxic metal ionic effects; at least one agent for normalizing or maintaining methyl metabolism in the body; at least one agent for normalizing or maintaining metabolism of insulin and glucose in the body; and at least one agent for up-regulating activity of heat shock proteins in the body. The composition is administered in the form of a breath-care strip, mint or lozenge, or a food or beverage product.

2007016, Jul 12, 2007

Feb 6, 2007

11/703446

Edward McCleary - Incline Village NV, US

A61K 38/43, A61K 38/38, A61K 31/714, A61K 31/7076, A61K 31/4188, A61K 31/455, A61K 31/4415

424094100, 514052000, 514012000, 514251000, 514184000, 514356000, 514350000, 514554000, 514560000, 514440000, 514561000, 514566000, 514047000, 514078000, 514564000, 514171000, 514102000, 514458000, 514547000

A combination of chemical agents reduces reductive stress by limiting the accumulation of high-energy electrons potentially available to the electron transport chain. A method of metabolic uncoupling therapy comprises: analyzing a specific physiologic process involving reductive stress; identifying a plurality of MUT agents that modulate metabolic pathways by influencing electron flux; and formulating a combination of MUT agents that limits the accumulation of high-energy electrons potentially available to the electron transport chain.

2007029, Dec 27, 2007

Aug 3, 2007

11/833474

Edward McCleary - Incline Village NV, US

A61K 36/53, A23L 1/30, A61K 36/82, A61P 25/30, A61K 9/00, A23L 2/00

424400000, 424729000, 424745000, 426590000, 426648000

Improved compositions and methods useful in the treatment and prevention of impulsive, compulsive, reward seeking, and other addictive behaviors, including applications involving the behavioral/cognitive process of assigning importance, maintaining attention, and assessing salience. The composition includes -(Chastetree berry) extract in an effective amount for supporting and promoting a healthy lifestyle free from addictive behavior or for preventing or treating addictive behavior. Huperzine and/or 5-HTP (5-hydroxytryptophan) may also be included. The composition may also include ingredients to address nutritional deficiencies in the addict, and nutrients depleted during the withdrawal of any reinforcer that is the object of the addiction.

2006010, May 18, 2006

Apr 21, 2005

11/111542

Edward McCleary - Incline Village NV, US

A61K 36/87, A61K 36/82, A61K 31/555, A61K 31/198, A61K 31/4188, A61K 31/385, A61K 31/32, A61K 31/225, A61K 31/185, A01N 33/12, A61K 36/185

424729000, 424769000, 424766000, 514184000, 514440000, 514547000, 514419000, 514566000, 514493000, 514553000, 514642000, 424439000, 514669000

Improved compositions and methods useful in the treatment and prevention of impulsive, compulsive, reward seeking, and other addictive behaviors, including applications involving the behavioral/cognitive process of assigning importance, maintaining attention, and assessing salience. The composition includes -(Chastetree berry) extract in an effective amount for supporting and promoting a healthy lifestyle free from addictive behavior or for preventing or treating addictive behavior. Huperzine and/or 5-HTP (5-hydroxytryptophan) may also be included. The composition may also include ingredients to address nutritional deficiencies in the addict, and nutrients depleted during the withdrawal of any reinforcer that is the object of the addiction.

2006006, Mar 23, 2006

Nov 12, 2005

11/271350

Edward McCleary - Incline Village NV, US

A61K 36/87, A61K 31/7048, A61K 31/198, A61K 36/82

424766000, 514184000, 514027000, 514456000, 514564000, 514548000, 424729000, 424769000

Improved compositions and methods are useful in the treatment and prevention of impulsive, compulsive, reward-seeking, and other addictive behaviors, including applications involving the behavioral/cognitive process of assigning importance, maintaining attention, and assessing salience. The composition includes Vitex agnus-castus (Chastetree berry) extract in an effective amount for supporting and promoting a healthy lifestyle free from addictive behavior or for preventing or treating addictive behavior. The composition also includes garcinia cambogia, aspartic acid, pyruvate, EPA (eicosapentanoic acid), biotin, L-carnitine, and chromium polynicotinate.