Edward J Vresilovic
Medical Practice in Ardmore, PA
License number
New Jersey 25MA06501800
Issued Date
Dec 11, 1996
Expiration Date
Jun 30, 2007
Category
Medical Examiners
Type
Medical Doctor
Address
Address
Ardmore, PA
Professional information
Supplementation Or Replacement Of A Nucleus Pulposus Of An Intervertebral Disc
US Patent:
2006012, Jun 8, 2006
Filed:
Jul 27, 2005
Appl. No.:
11/189753
Inventors:
Edward Vresilovic - Ardmore PA, US
Michael Keane - Downingtown PA, US
Thomas Schaer - Landenberg PA, US
Michael Keane - Downingtown PA, US
Thomas Schaer - Landenberg PA, US
International Classification:
A61F 2/44
US Classification:
623017160
Abstract:
A degenerated nucleus pulposus located in a central core region of an intervertebral disc within the annulus fibrosus is supplemented or replaced by a method wherein an amount of a biocompatible material is introduced into the central core region by a process including the steps of 1) forming a channel through a vertebral body adjacent to said intervertebral disc, extending from an exterior surface of the vertebral body to the central core region of the annulus fibrosus; 2) introducing an amount of a biocompatible material through the channel into the central core region of the annulus fibrosus; 3) pressurizing the biocompatible material through the channel to a postsurgical pressure sufficient to alleviate symptoms caused by the degenerated nucleus pulposus; and 4) sealing the channel while maintaining the sufficient postsurgical pressure. After sealing the channel, a vertebroplasty may optionally be performed in the vertebra.
Hydrogel Balloon Prosthesis For Nucleus Pulposus
US Patent:
2010004, Feb 25, 2010
Filed:
Oct 29, 2009
Appl. No.:
12/608565
Inventors:
Edward Vresilovic - Ardmore PA, US
Michele S. Marcolongo - Aston PA, US
Anthony M. Lowman - Wallingford PA, US
Alastair J. T. Clemow - Princeton NJ, US
Michael F. Keane - Downington PA, US
Michele S. Marcolongo - Aston PA, US
Anthony M. Lowman - Wallingford PA, US
Alastair J. T. Clemow - Princeton NJ, US
Michael F. Keane - Downington PA, US
International Classification:
A61L 33/04
US Classification:
427 224
Abstract:
A prosthesis for replacing or supplementing a nucleus pulposus of an intervertebral disk is an expandable container having flexible walls, the container being adapted to be inserted into a central cavity of an intervertebral disk through a narrow cannula, and the flexible walls are made from a biocompatible hydrogel. A preferred hydrogel is a cryogel formed from an aqueous solution of poly(vinyl alcohol) and poly(vinyl pyrrolidone). The prosthesis may be prepared by dip-coating a mandrel with an aqueous solution of a hydrogel-forming polymer or mixture of such polymers, gelling the coated solution by chilling, and subjecting the gelled coating to a series of repeated freeze-thaw treatments. In use, the prosthesis is inserted into a central cavity of an intervertebral disk and filled with biocompatible material, e.g., a biocompatible liquid, a biocompatible polymer, and a biocompatible hydrogel, particularly a thermogelling hydrogel.
Method And Apparatus For Implanting A Hydrogel Prosthesis For A Nucleus Pulposus
US Patent:
7850730, Dec 14, 2010
Filed:
Mar 29, 2006
Appl. No.:
11/391245
Inventors:
Edward Vresilovic - Ardmore PA, US
Michael Keane - Dowingtown PA, US
Thomas Peter Schaer - Landenberg PA, US
Amy Arthur - Philadelphia PA, US
Michael Keane - Dowingtown PA, US
Thomas Peter Schaer - Landenberg PA, US
Amy Arthur - Philadelphia PA, US
Assignee:
Synthes USA, LLC - West Chester PA
International Classification:
A61F 2/44
US Classification:
623 1711, 623 1712, 606 99, 606 86 R
Abstract:
An instrument for inserting an elongated hydrogel prosthesis into an intervertebral disc includes an insertion cannula that is inserted through the annulus fibrosus of an intervertebral disc to provide access to the nucleus region of the disc, an elongated hydrogel prosthesis packaged within a tubular container adapted to be coupled to a proximal end of the insertion cannula, and a source of fluid pressure adapted to be coupled to a proximal end of the tubular container. Auxiliary instruments for use in convenient insertion of the insertion cannula through the nucleus pulposus and providing for a complete and controlled passage of the hydrogel prosthesis through the insertion cannula are provided in a kit with the insertion cannula. A sizing apparatus for determining the volume of prosthesis to be inserted includes a catheter or cannula capable of being inserted through the insertion cannula into the nucleus region of the intervertebral disc and having at its distal end a balloon capable of being inflated within the intervertebral disc with a measurable volume of a fluid in order to determine the amount of hydrogel prosthesis to be injected.
Supplementation Or Replacement Of A Nucleus Pulposus Of An Intervertebral Disc
US Patent:
8147553, Apr 3, 2012
Filed:
Jun 27, 2008
Appl. No.:
12/163407
Inventors:
Edward Vresilovic - Ardmore PA, US
Michael F. Keane - Downingtown PA, US
Thomas P. Schaer - Landenberg PA, US
Michael F. Keane - Downingtown PA, US
Thomas P. Schaer - Landenberg PA, US
Assignee:
Synthes USA, LLC - West Chester PA
International Classification:
A61F 2/44
US Classification:
623 1716
Abstract:
A degenerated nucleus pulposus located in a central core region of an intervertebral disc within the annulus fibrosus is supplemented or replaced by a method wherein an amount of a biocompatible material is introduced into the central core region by a process including the steps of 1) forming a channel through a vertebral body adjacent to said intervertebral disc, extending from an exterior surface of the vertebral body to the central core region of the annulus fibrosus; 2) introducing an amount of a biocompatible material through the channel into the central core region of the annulus fibrosus; 3) pressurizing the biocompatible material through the channel to a postsurgical pressure sufficient to alleviate symptoms caused by the degenerated nucleus pulposus; and 4) sealing the channel while maintaining the sufficient postsurgical pressure. After sealing the channel, a vertebroplasty may optionally be performed in the vertebra.
Replacement Or Supplementation Of A Nucleus Pulposus Using A Hydrogel
US Patent:
2006010, May 11, 2006
Filed:
May 23, 2005
Appl. No.:
11/134309
Inventors:
Edward Vresilovic - Ardmore PA, US
Michael Keane - Downingtown PA, US
Alastair Clemow - Princeton NJ, US
Nigel Smith - Dovon PA, US
Michael Keane - Downingtown PA, US
Alastair Clemow - Princeton NJ, US
Nigel Smith - Dovon PA, US
International Classification:
A61F 2/44, A61F 2/46, A61B 17/90, A61F 2/00, A61B 17/00, A61L 27/00
US Classification:
523113000, 623017160, 606079000, 427002260
Abstract:
A nucleus pulposus of an intervertebral disc is supplemented or replaced by an elongated, physiologically fully hydrated hydrogel prosthesis inserted into the central region of an intervertebral disc, where it can fold upon itself to form a prosthesis body within the central region of the annulus fibrosus. The hydrogel prosthesis may have expanded portions that assist in preventing expulsion of the prosthesis through the insertion aperture. An instrument for inserting the prosthesis has a cutter for severing the elongated prosthesis within the central region of the intervertebral disc after a sufficient amount has been implanted.
Modular Spinal Fixation System
US Patent:
7785352, Aug 31, 2010
Filed:
Jul 13, 2007
Appl. No.:
11/879023
Inventors:
Brian D. Snyder - Westwood MA, US
Edward J. Vresilovic - Ardmore PA, US
Hemal P. Mehta - Washington DC, US
John A. Muller - Boston MA, US
Edward J. Vresilovic - Ardmore PA, US
Hemal P. Mehta - Washington DC, US
John A. Muller - Boston MA, US
Assignee:
Mass Modular Spine Group, Inc. - Westwood MA
International Classification:
A61B 17/70
US Classification:
606263, 606264
Abstract:
A spinal fixation system having a modular construction to allow universal application to varying spine anatomy and load requirements of individual vertebral attachment members, while reducing requirements for large inventories to optimize spinal fixation. Modularity allows the individual attachment members, once attached optimally to bone, to be attached to a variety of interconnecting structural members optimized for load carrying capacity.
Replacement Or Supplementation Of A Nucleus Pulposus Using A Hydrogel
US Patent:
2012014, Jun 7, 2012
Filed:
Jan 17, 2012
Appl. No.:
13/351531
Inventors:
Edward VRESILOVIC - Ardmore PA, US
Michael F. KEANE - Downingtown PA, US
Alastair J.T. CLEMOW - Princeton NJ, US
Nigel G. SMITH - Norwich, GB
Michael F. KEANE - Downingtown PA, US
Alastair J.T. CLEMOW - Princeton NJ, US
Nigel G. SMITH - Norwich, GB
Assignee:
Synthes USA, LLC - West Chester PA
International Classification:
A61F 2/44
US Classification:
623 1716
Abstract:
A nucleus pulposus of an intervertebral disc is supplemented or replaced by a physiologically fully hydrated solid hydrogel intervertebral body comprising a polyvinyl alcohol copolymer, wherein the solid hydrogel intervertebral body exhibits an osmotic pressure of from 0.1 to 0.3 megapascals prior to insertion into a patient, the solid hydrogel intervertebral body having a ratio of length to principal transverse dimension not less than about 5:1.
Compositions And Methods For Treating A Disorder Or Defect In Soft Tissue
US Patent:
2013005, Feb 28, 2013
Filed:
Nov 9, 2010
Appl. No.:
13/508466
Inventors:
Michele Marcolongo - Aston PA, US
Edward Vresilovic - Ardmore PA, US
Benjamin Jackson - Chadds Ford PA, US
Sumona Sarkar - Silver Spring MD, US
Caroline Schauer - Hulmeville PA, US
Edward Vresilovic - Ardmore PA, US
Benjamin Jackson - Chadds Ford PA, US
Sumona Sarkar - Silver Spring MD, US
Caroline Schauer - Hulmeville PA, US
International Classification:
C07K 17/08, A61K 31/78, A61K 38/39, A61P 19/00, C08G 63/91, A61P 9/00, A61P 19/04, A61P 27/02, A61P 25/00, A61P 19/02, A61K 31/765, A61P 17/00
US Classification:
424 7827, 514 171, 525 541, 530395
Abstract:
The present invention encompasses methods and compositions for generating a biomimetic proteoglycan. The invention includes methods of treating a disease, disorder, or condition of soft tissue using a biomimetic proteoglycan.
Replacement Or Supplementation Of A Nucleus Pulposus Using A Hydrogel
US Patent:
8118874, Feb 21, 2012
Filed:
Sep 28, 2009
Appl. No.:
12/568577
Inventors:
Edward Vresilovic - Ardmore PA, US
Michael F. Keane - Downingtown PA, US
Alastair J. T. Clemow - Princeton NJ, US
Nigel G. Smith - Norwich, GB
Michael F. Keane - Downingtown PA, US
Alastair J. T. Clemow - Princeton NJ, US
Nigel G. Smith - Norwich, GB
Assignee:
Synthes USA, LLC - West Chester PA
International Classification:
A61F 2/44
US Classification:
623 1716
Abstract:
A nucleus pulposus of an intervertebral disc is supplemented or replaced by an elongated, physiologically fully hydrated hydrogel prosthesis inserted into the central region of an intervertebral disc, where it can fold upon itself to form a prosthesis body within the central region of the annulus fibrosus. The hydrogel prosthesis may have expanded portions that assist in preventing expulsion of the prosthesis through the insertion aperture. An instrument for inserting the prosthesis has a cutter for severing the elongated prosthesis within the central region of the intervertebral disc after a sufficient amount has been implanted.
Tension Fixation System
US Patent:
8211152, Jul 3, 2012
Filed:
Feb 28, 2008
Appl. No.:
12/039128
Inventors:
Brian D. Snyder - Westwood MA, US
Edward J. Vresilovic - Ardmore PA, US
Hemal P. Mehta - Clarksville TN, US
John A. Muller - Boston MA, US
Edward J. Vresilovic - Ardmore PA, US
Hemal P. Mehta - Clarksville TN, US
John A. Muller - Boston MA, US
Assignee:
Mass Modular Spine Group, Inc. - Westwood MA
International Classification:
A61B 17/70
US Classification:
606267, 606264
Abstract:
The present invention provides an apparatus and method for fixation of a bone anchor to a structural member used for spinal fixation, whereby spinal deformity can be corrected and mechanical stability of the spine is provided so that load is carried fully or partially through the structural member. This invention provides fixation of a bone anchor to a structural member through tensile loading of a component of the fixation mechanism. This invention is widely adaptable to a variety of bone anchors and structural members. This invention allows reduction of spine deformity resulting from varied spinal disease through the fixation mechanism alone without the need for added reduction instrumentation systems. This invention equally provides a fixation mechanism for fixation of a bone anchor to the structural member of a spine fixation system in the absence of deformity.