Inventors:
Nigel H. Greig - Phoenix MD, US
Weiming Luo - Lutherville MD, US
David Tweedie - Baltimore MD, US
Harold W. Holloway - Middle River MD, US
Edward J. Goetzl - San Francisco CA, US
International Classification:
A61K 31/454, A61P 25/28, A61P 25/16, A61P 27/02, A61P 19/02, A61P 25/14, A61P 25/02, C07D 401/04, A61P 29/00
Abstract:
A compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of:wherein A, B and D are each oxygen or sulfur, provided that least one of A, B and D is sulfur; and R-Rare each independently hydrogen, hydroxyl, acyl, substituted acyl, acyloxy, substituted acyloxy, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, alkoxy, substituted alkoxy, aryl, substituted aryl, amino, substituted amino, halogen, heterocycloalkyl, substituted heterocycloalkyl, heteroaryl, substituted heteroaryl, or a thio-containing group.