Inventors:
Edward E. Winger - San Francisco CA, US
Jane L. Reed - Klamath Falls OR, US
International Classification:
C12Q 1/68
Abstract:
The invention is directed to methods and compositions for collecting immune cells, preferably peripheral blood mononuclear cells (PBMCs), before or after an intervention, extracting microRNA-comprising RNA from said cells, quantifying microRNAs within the extracted RNA, determining one or more microRNAs that display a bimodal response amongst a statistically sufficient number of patient samples. Patients are then preferably segregated into groups according to their response.