DR. EDWARD DAVID CRANDALL, M.D.
Osteopathic Medicine at San Pablo St, Los Angeles, CA
License number
California G28278
Category
Osteopathic Medicine
Type
Critical Care Medicine
License number
California G28278
Category
Osteopathic Medicine
Type
Pulmonary Disease
Address
Address
1520 San Pablo St SUITE 1000, Los Angeles, CA 90033
Phone
(323) 442-5100
Personal information
See more information about EDWARD DAVID CRANDALL at radaris.comName
Address
Phone
930 Oak Park Dr, Morgan Hill, CA 95037
8099 B St, Windsor, CA 95492
5718 Silver Leaf Rd, San Jose, CA 95138
21 Winfield St, San Francisco, CA 94110
2002 Greenfield Ave, Los Angeles, CA 90025
Professional information
Md, Phd At University Of Southern California
Position:
MD, PhD at University of Southern California
Location:
Greater Los Angeles Area
Industry:
Medical Practice
Work:
University of Southern California
-
MD, PhD
Education:
University of Pennsylvania School of Medicine 1968 - 1972
Edward David Crandall, Los Angeles CA
Specialties:
Internal Medicine, Pulmonary Disease, Critical Care Medicine, Medical Genetics
Work:
Ambulatory Health Center
1520 San Pablo St, Los Angeles, CA 90033 Usc Internal Medicine
1355 San Pablo St, Los Angeles, CA 90033
1520 San Pablo St, Los Angeles, CA 90033 Usc Internal Medicine
1355 San Pablo St, Los Angeles, CA 90033
Education:
University of Pennsylvania(1972)
Edward David Crandall, Los Angeles CA
Specialties:
Pulmonologist
Address:
1520 San Pablo St, Los Angeles, CA 90033
2020 Zonal Ave, Los Angeles, CA 90089
2020 Zonal Ave, Los Angeles, CA 90089
Education:
University of Pennsylvania, Perelman School of Medicine - Doctor of Medicine
Pennsylvania Hospital - Fellowship - Pulmonary Disease (Internal Medicine)
Pennsylvania Hospital - Residency - Family Medicine
Pennsylvania Hospital - Fellowship - Pulmonary Disease (Internal Medicine)
Pennsylvania Hospital - Residency - Family Medicine
Board certifications:
American Board of Internal Medicine Certification in Internal Medicine, American Board of Internal Medicine Sub-certificate in Pulmonary Disease (Internal Medicine)
Lentivirus Vectors For Gene Transfer To Alveolar Epithelial Cells
US Patent:
2002018, Dec 5, 2002
Filed:
Apr 9, 2002
Appl. No.:
10/119499
Inventors:
Zea Borok - Los Angeles CA, US
Nori Kasahara - Los Angeles CA, US
Edward Crandall - Los Angeles CA, US
Nori Kasahara - Los Angeles CA, US
Edward Crandall - Los Angeles CA, US
Assignee:
University of Southern California - Los Angeles CA
International Classification:
C12N015/867, C12N007/00
US Classification:
435/456000, 435/235100, 435/320100
Abstract:
The present invention demonstrates that VSV-G-pseudotyped lentivirus vectors efficiently transduce AEC in primary culture and in vivo with transduction favored by virus application from the apical side. Transduction efficiency in AEC increased with increasing MOI and greatly exceeded that achieved with a similarly pseudotyped MLV retrovirus vector. The present invention also demonstrates the successful in vivo transfer of genes through lentivirus vector transduction. Mammals injected with lentivirus vector via the trachea expressed the reporter protein in alveolar epithelial cells within 48 to 72 hours after infection.
Lentivirus Vectors For Gene Transfer To Alveolar Epithelial Cells
US Patent:
7601345, Oct 13, 2009
Filed:
Mar 9, 2007
Appl. No.:
11/716173
Inventors:
Zea Borok - Los Angeles CA, US
Nori Kasahara - Los Angeles CA, US
Edward Crandall - Los Angeles CA, US
Nori Kasahara - Los Angeles CA, US
Edward Crandall - Los Angeles CA, US
Assignee:
University of Southern California - Los Angeles CA
International Classification:
A01N 63/00, A61K 48/00, C12N 15/00, C12N 15/63
US Classification:
424 9321, 424 932, 424 936, 4353201, 435455
Abstract:
The present invention demonstrates that VSV-G-pseudotyped lentivirus vectors efficiently transduce AEC in primary culture and in vivo with transduction favored by virus application from the apical side. Transduction efficiency in AEC increased with increasing MOI and greatly exceeded that achieved with a similarly pseudotyped MLV retrovirus vector. The present invention also demonstrates the successful in vivo transfer of genes through lentivirus vector transduction. Mammals injected with lentivirus vector via the trachea expressed the reporter protein in alveolar epithelial cells within 48 to 72 hours after infection.