DR. EDWARD CHAUM, MD PHD
Medical Practice at Madison Ave, Memphis, TN

2014005, Feb 27, 2014

Nov 5, 2013

14/072370

Edward Chaum - Memphis TN, US
John T. Simpson - Clinton TN, US
Justin S. Baba - Knoxville TN, US
M. Nance Ericson - Knoxville TN, US
Robert J. Warmack - Knoxville TN, US

UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION - Knoxville TN
UT-BATTELLE, LLC - Oak Ridge TN

A61F 9/007

606166

In one embodiment, the present invention provides a device and method for treating recurrent corneal erosion. In one embodiment, the method includes the steps of contacting an epithelium layer of a cornea with an array of glass micro-rods including a plurality of sharp features having a length that penetrates a Bowman's layer of the eye, wherein the plurality of sharp features of the array of glass micro-rods produces a plurality of punctures in the Bowman's layer of the eye that are of micro-scale or less. In another embodiment, the present invention provides a method and device for drug delivery. In one embodiment, the device includes an array of glass micro-rods, wherein at least one glass micro-rod of the array of glass micro-rods includes a sharp feature opposite a base of the array of glass micro-rods, wherein the sharp feature includes a treated surface for delivering a chemical compound to the eye.

8243999, Aug 14, 2012

May 3, 2006

11/416834

Thomas P. Karnowski - Knoxville TN, US
Edward Chaum - Memphis TN, US

UT-Battelle, LLC - Oak Ridge TN

G06K 9/00

382115

A method for diagnosing diseases having retinal manifestations including retinal pathologies includes the steps of providing a CBIR system including an archive of stored digital retinal photography images and diagnosed patient data corresponding to the retinal photography images, the stored images each indexed in a CBIR database using a plurality of feature vectors, the feature vectors corresponding to distinct descriptive characteristics of the stored images. A query image of the retina of a patient is obtained. Using image processing, regions or structures in the query image are identified. The regions or structures are then described using the plurality of feature vectors. At least one relevant stored image from the archive based on similarity to the regions or structures is retrieved, and an eye disease or a disease having retinal manifestations in the patient is diagnosed based on the diagnosed patient data associated with the relevant stored image(s).

2008031, Dec 18, 2008

Apr 28, 2006

11/912446

Edward Chaum - Memphis TN, US
John Lang - Cedar Hill TX, US

A61K 38/02, C12Q 1/02, C12Q 1/26, C12Q 1/68, A61K 31/375

514 2, 435 29, 435 25, 435 6

The invention encompasses cell-based systems comprising biomarkers that respond to oxidative stress (OS) in a quantitative manner, and methods of use thereof. The systems are useful for screening, identifying and testing antioxidant agents, combinations, and formulations thereof for preventing, treating, or reducing symptoms of conditions associated with oxidative damage to cells. The cell-based systems are useful for identifying effective new antioxidant agents and for optimizing antioxidant formulations for targeted therapeutic applications. One cell-based system utilizes RPE cells of the eye for identifying and optimizing antioxidant compositions effective for treatment of age-related conditions such as macular degeneration. The cell-based systems provide a convenient, inexpensive and physiologically relevant in vitro alternative to human population-based methods for testing efficacy of nutritional and pharmaceutical compositions comprising antioxidants. The invention further encompasses nutritional or pharmaceutical compositions targeting particular diseases such as AMD, formulated using methods as disclosed herein.

2012011, May 10, 2012

Oct 15, 2009

13/124036

Edward Chaum - Memphis TN, US
Erno Lindner - Germantown TN, US
Kenneth C. Curley - Frederick MD, US
Jidong Guo - Chungchun City, CN

THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION - Knoxville TN
UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE ARMY - Fort Detrick MD
THE UNIVERSITY OF MEMPHIS RESEARCH FOUNDATION - Memphis TN

A61B 5/1473, G01N 33/50, G01N 27/327, A61M 5/168, B82Y 30/00, B82Y 99/00, B82Y 5/00

600345, 20440306, 2057825, 604 65, 604503, 977742, 977920, 977700

The invention relates to a method for the controlled delivery of a drug as a function of bioavailable drug concentration, a sensor device for detecting bioavailable drug concentration, and a delivery device that controls delivery of the drug based on the real-time detection of bioavailable drug concentration.

2003018, Oct 2, 2003

Mar 26, 2003

10/397933

Edward Chaum - Germantown TN, US

The University of Tennessee Research Corporation - Memphis TN

A61K048/00

514/044000, 424/093210

Disclosed are methods and compositions for growth factor gene therapy for conditions involving degeneration or injury of cells of the retina, including age-related macular degeneration. Included in the invention are non-viral vectors for delivery of growth factor fusion proteins, cells transduced with such vectors, and methods of treatment using these vectors.

2013031, Nov 21, 2013

Apr 22, 2013

13/867783

University of Tennessee Research Foundation - , US
Edward CHAUM - Memphis TN, US
John T. SIMPSON - Clinton TN, US
Justin S. BABA - Knoxville TN, US
M. Nance ERICSON - Knoxville TN, US
Robert J. WARMACK - Knoxvile TN, US

University of Tennessee Research Foundation - Knoxvilee TN
UT-Battelle, LLC - Oak Ridge TN

A61F 9/007

606162

In one embodiment, the present invention provides a method of removing scar tissue from an eye that includes inserting a device including an array of micro-rods into an eye, wherein at least one glass micro-rod of the array of glass micro-rods includes a sharp feature; contacting a scar tissue with the array of micro-rods; and removing the array of micro-rods and the scar tissue from the eye. In another embodiment, the present invention provides a medical device for engaging a tissue including and an array of glass micro-rods, wherein at least one glass micro-rod of the array of glass micro-rods includes a sharp feature opposite a base of the array of glass micro-rods that is connected to the cannula, wherein the sharp feature of the at least one micro-rod is angled from a plane that is normal to a face of the base of the array of glass micro-rods.