EDWARD ANDREW HILL
Pilots at Masters Ln, Wilmington, NC
License number
North Carolina A4653119
Issued Date
Jun 2013
Expiration Date
Jun 2014
Category
Airmen
Type
Authorized Aircraft Instructor
Address
Address
5806 Masters Ln, Wilmington, NC 28409
Professional information
Estrogenic Compounds, Pharmaceutical Compositions Thereof, And Methods Of Using Same
US Patent:
6660726, Dec 9, 2003
Filed:
Mar 8, 2001
Appl. No.:
09/800614
Inventors:
Edward N. Hill - Wilmington NC
Frederick D. Sancilio - Wilmington NC
Robert R. Whittle - Wilmington NC
Frederick D. Sancilio - Wilmington NC
Robert R. Whittle - Wilmington NC
Assignee:
Endeavor Pharmaceuticals - Wilmington NC
International Classification:
A61K 3156
US Classification:
514178, 514182, 552615
Abstract:
Novel estrogenic compounds of Formula I are provided. wherein the bond represented by the wavy line may be a single or double bond such that when the wavy line is a single bond, R is selected from the group consisting of hydrogen, sulfate and glucoronate or other esters, and when the wavy line is a double bond, R does not exist; R is lower alkyl; R may be selected from the group consisting of hydrogen, sulfate, or glucuronide or other esters; and R through R may independently be selected from the group consisting of hydrogen, hydroxy, ketone, lower alkyl, lower alkoxy, halogen, and carbonyl groups and R is selected from the group consisting of hydrogen, sulfate and glucoronide and other esters. When R is hydroxy, the hydroxy or ester substituent may have either an or a orientation. Compositions of matter including compounds of the present invention are also provided as are methods of treating mammals in need of treatment using compounds of the present invention.
Pharmaceutical Compositions Of Conjugated Estrogens And Methods Of Analyzing Mixtures Containing Estrogenic Compounds
US Patent:
6855703, Feb 15, 2005
Filed:
Mar 10, 2000
Appl. No.:
09/524132
Inventors:
Edward N. Hill - Wilmington NC, US
Thomas W. Leonard - Wilmington NC, US
Frederick D. Sancilio - Wilmington NC, US
Katherin M. Schlipp - Wilmington NC, US
Dean G. Shirazi - Wilmington NC, US
Robert R. Whittle - Wilmington NC, US
Thomas W. Leonard - Wilmington NC, US
Frederick D. Sancilio - Wilmington NC, US
Katherin M. Schlipp - Wilmington NC, US
Dean G. Shirazi - Wilmington NC, US
Robert R. Whittle - Wilmington NC, US
Assignee:
Endeavor Pharmaceuticals - Wilmington NC
International Classification:
A61K031/56
US Classification:
514170
Abstract:
A composition of matter is provided having a mixture of active estrogenic compounds. The mixture is present in chemically pure form. The mixture includes salts of conjugated estrone, conjugated equilin, conjugated Δ-dehydroestrone, conjugated 17α-estradiol, conjugated 17α-dihydroequilin, conjugated 17β-dihydroequilin, conjugated 17β-estradiol, conjugated equilenin, conjugated 17α-dihydroequilenin, and conjugated 17β-dihydroequilenin. The mixture also contains the same essential estrogenic compounds present in naturally derived equine conjugated estrogens. Drug products including the composition of matter are also provided, as are methods of using these drug products to treat mammals in need of treatment. Methods of analyzing mixtures containing conjugated estrogens are also provided.
(3) And (6) Substitued Estrogenic Compounds
US Patent:
6844334, Jan 18, 2005
Filed:
May 15, 2003
Appl. No.:
10/438585
Inventors:
Edward N. Hill - Wilmington NC, US
Frederick D. Sancilio - Wilmington NC, US
Robert R. Whittle - Wilmington NC, US
Frederick D. Sancilio - Wilmington NC, US
Robert R. Whittle - Wilmington NC, US
Assignee:
Endeavor Pharmaceuticals - Wilmington DE
International Classification:
A61K 3156, C07J 100
US Classification:
514178, 514182, 552615
Abstract:
Novel estrogenic compounds of Formula I are provided. wherein the bond represented by the wavy line may be a single or double bond such that when the wavy line is a single bond, Ris selected from the group consisting of hydrogen, sulfate and glucoronate or other esters, and when the wavy line is a double bond, Rdoes not exist; Ris lower alkyl; Rmay be selected from the group consisting of hydrogen, sulfate, or glucuronide or other esters; and Rthrough Rmay independently be selected from the group consisting of hydrogen, hydroxy, ketone, lower alkyl, lower alkoxy, halogen, and carbonyl groups and Ris selected from the group consisting of hydrogen, sulfate and glucoronide and other esters. When Ris hydroxy, the hydroxy or ester substituent may have either an α or a β orientation. Compositions of matter including compounds of the present invention are also provided as are methods of treating mammals in need of treatment using compounds of the present invention.
Estrogenic Compounds, Pharmaceutical Compositions And Formulations Comprising The Same
US Patent:
8227454, Jul 24, 2012
Filed:
Jun 23, 2011
Appl. No.:
13/167350
Inventors:
Edward N. Hill - Wilmington NC, US
Frederick D. Sancilio - Wilmington NC, US
Robert R. Whittle - Wilmington NC, US
Frederick D. Sancilio - Wilmington NC, US
Robert R. Whittle - Wilmington NC, US
Assignee:
Duramed Pharmaceuticals, Inc. - Cincinnati OH
International Classification:
A61K 31/566, A61K 31/565
US Classification:
514178, 514170, 514171, 514182
Abstract:
Novel estrogenic compounds of Formula I are provided.
Estrogenic Compounds And Topical Pharmaceutical Formulations Of The Same
US Patent:
7459445, Dec 2, 2008
Filed:
Feb 6, 2007
Appl. No.:
11/671718
Inventors:
Edward N. Hill - Wilmington NC, US
Frederick D. Sancilio - Wilmington NC, US
Robert R. Whittle - Wilmington NC, US
Frederick D. Sancilio - Wilmington NC, US
Robert R. Whittle - Wilmington NC, US
Assignee:
Duramed Pharmaceuticals, Inc. - Cincinnati OH
International Classification:
A61K 31/56, C07J 1/00
US Classification:
514182, 514171, 514178, 552615
Abstract:
Novel estrogenic compounds of Formula I are provided.
C(14) Estrogenic Compounds
US Patent:
6992075, Jan 31, 2006
Filed:
Apr 4, 2003
Appl. No.:
10/407509
Inventors:
Edward N. Hill - Wilmington NC, US
Thomas W. Leonard - Wilmington NC, US
Robert R. Whittle - Wilmington NC, US
Thomas W. Leonard - Wilmington NC, US
Robert R. Whittle - Wilmington NC, US
Assignee:
Barr Laboratories, Inc. - Woodcliffe Lake NJ
International Classification:
A61K 31/56, C07J 1/00
US Classification:
514179, 514182, 552618
Abstract:
The present invention relates to novel estrogenic compounds. The present invention also relates to methods of treating estrogen deprivation in a subject comprising administering novel estrogenic compounds. Additionally, the present invention relates to methods of synthesizing novel estrogenic compounds.
(3) And (6) Substituted Estrogenic Compounds
US Patent:
7179799, Feb 20, 2007
Filed:
Jul 23, 2003
Appl. No.:
10/628057
Inventors:
Edward N. Hill - Wilmington NC, US
Frederick D. Sancilio - Wilmington NC, US
Robert R. Whittle - Wilmington NC, US
Frederick D. Sancilio - Wilmington NC, US
Robert R. Whittle - Wilmington NC, US
Assignee:
Barr Laboratories, Inc. - Woodcliff Lake NJ
International Classification:
A61K 31/56, C07J 1/00
US Classification:
514178, 514170, 514171, 514182, 552615
Abstract:
Novel estrogenic compounds of Formula I are provided.
Estrogenic Compounds And Pharmaceutical Formulations Comprising The Same
US Patent:
7989436, Aug 2, 2011
Filed:
May 27, 2010
Appl. No.:
12/788450
Inventors:
Edward N. Hill - Wilmington NC, US
Frederick D. Sancilio - Wilmington NC, US
Robert R. Whittle - Wilmington NC, US
Frederick D. Sancilio - Wilmington NC, US
Robert R. Whittle - Wilmington NC, US
Assignee:
Duramed Pharmaceuticals, Inc. - Cincinnati OH
International Classification:
A61K 31/56, C07J 1/00
US Classification:
514171, 552615
Abstract:
Novel estrogenic compounds of Formula I are provided.
Estrogenic Compounds, Methods Of Using And Methods Of Administering The Same
US Patent:
7749989, Jul 6, 2010
Filed:
Nov 24, 2008
Appl. No.:
12/276511
Inventors:
Edward N. Hill - Wilmington NC, US
Frederick D. Sancilio - Wilmington NC, US
Robert R. Whittle - Wilmington NC, US
Frederick D. Sancilio - Wilmington NC, US
Robert R. Whittle - Wilmington NC, US
Assignee:
Duramed Pharmaceuticals, Inc. - Cincinnati OH
International Classification:
A61K 31/566, C07J 1/00
US Classification:
514178, 514171, 514182, 552615
Abstract:
Novel estrogenic compounds of Formula I are provided.