DR. EDWARD ALAN BURTON, MD, DPHIL, FRCP
Neurology at Lillian, Pittsburgh, PA

7205124, Apr 17, 2007

Oct 4, 2000

10/089928

Edward Burton - Pittsburgh PA, US
Jonathan Tinsley - Oxford, GB
Kay Davies - Oxford, GB

Isis Innovation Limited - Oxford

C12P 21/02

435 691, 4353201, 43525233, 435471, 536 241

Second promoter for mouse and human utrophin genes. The promoters or fragments and derivatives may be used to control transcription of heterologous sequences, including coding sequences of reporter genes. Expression systems such as host cells containing nucleic acid constructs which comprise a promoter as provided operably linked to a heterologous sequence may be used to screen substances for ability to modulate activity of the utrophin promoter. Substances with such ability may be manufactured and/or used in the preparation of compositions such as medicaments. Up-regulation of utrophin expression may compensate for dystrophin loss in muscular dystrophy patients.