Inventors:
John H. Griffin - Del Mar CA
Samuel I. Rapaport - La Jolla CA
Dzung T. Le - San Diego CA
Assignee:
The Scripps Research Institute - La Jolla CA
The Regents of the University of California - Oakland CA
International Classification:
C12Q 156, C12Q 100, G01N 3353, G01N 3300
Abstract:
The present invention provides an in vitro method useful for the diagnosis of a thrombotic disorder in a subject, having or at risk of having the disorder. Specifically, the disorder exemplified herein is associated with APC resistant Factor V and Va. The clotting time of a test sample is analyzed in the presence and absence of APC and compared with a standard reference sample in order to diagnose the subject.