DUXIN SUN
Pharmacy in Ann Arbor, MI
License number
Michigan 5304000898
Issued Date
Oct 18, 2011
Expiration Date
Jun 30, 2018
Category
Pharmacy
Type
CS - Research Lab
Address
Address
Ann Arbor, MI 48109
Professional information
Fluorescence Detection System
US Patent:
2009023, Sep 17, 2009
Filed:
Jan 12, 2009
Appl. No.:
12/352408
Inventors:
Edward W. Martin - Delaware OH, US
Ronald X. Xu - Columbus OH, US
Duxin Sun - Ann Arbor MI, US
Stephen P. Povoski - Dublin OH, US
Joseph Pierre Heremans - Upper Arlington OH, US
Robert Lee - Hilliard OH, US
Vish V. Subramaniam - Westerville OH, US
Claudia Turro - Powell OH, US
Ronald X. Xu - Columbus OH, US
Duxin Sun - Ann Arbor MI, US
Stephen P. Povoski - Dublin OH, US
Joseph Pierre Heremans - Upper Arlington OH, US
Robert Lee - Hilliard OH, US
Vish V. Subramaniam - Westerville OH, US
Claudia Turro - Powell OH, US
Assignee:
The Ohio State University Research Foundation - Columbus OH
International Classification:
A61B 6/00, A61K 49/00
US Classification:
600431, 424 96
Abstract:
Exemplary embodiments include systems, methods, and compositions for the intra-operative detection of target tissue. At least one embodiment includes a fluorescence detection instrument that may be used for intra-operative detection of a fluorescent targeting agent, its binding site, and its interaction within cancer tissues. An exemplary embodiment is highly sensitive to the local deposition of fluorescence agents even at a low concentration. In at least one embodiment, the system includes a handheld navigation instrument that is usable to excite, detect, and report the fluorescent deposition of the targeting agent in real-time. In alternative embodiments, the system includes a wearable unit to excite, detect, and visually report the fluorescent deposition of the targeting agent to the user. The wearable unit includes eyewear that allow the user to perform image-guided surgery based on the near real-time fluorescence detection of the fluorescent targeting agent.
Spiro-Oxindole Mdm2 Antagonists
US Patent:
8518984, Aug 27, 2013
Filed:
Nov 12, 2010
Appl. No.:
12/945511
Inventors:
Shaomeng Wang - Saline MI, US
Shanghai Yu - Ann Arbor MI, US
Wei Sun - Ann Arbor MI, US
Sanjeev Kumar - Ann Arbor MI, US
Duxin Sun - Ann Arbor MI, US
Peng Zou - Ann Arbor MI, US
Donna McEachern - Ann Arbor MI, US
Yujun Zhao - Ann Arbor MI, US
Shanghai Yu - Ann Arbor MI, US
Wei Sun - Ann Arbor MI, US
Sanjeev Kumar - Ann Arbor MI, US
Duxin Sun - Ann Arbor MI, US
Peng Zou - Ann Arbor MI, US
Donna McEachern - Ann Arbor MI, US
Yujun Zhao - Ann Arbor MI, US
Assignee:
The Regents of the University of Michigan - Ann Arbor MI
International Classification:
C07D 487/10, A61K 31/4015
US Classification:
514409, 548406
Abstract:
Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.
Bcl-2/Bcl-Xl Inhibitors And Therapeutic Methods Using The Same
US Patent:
2012018, Jul 26, 2012
Filed:
Jan 24, 2012
Appl. No.:
13/356763
Inventors:
Shaomeng Wang - Saline MI, US
Haibin Zhou - Ann Arbor MI, US
Jianfang Chen - Ann Arbor MI, US
Angelo Aguilar - Ann Arbor MI, US
Jennifer L. Meagher - Plymouth MI, US
Duxin Sun - Ann Arbor MI, US
Chao-Yie Yang - Ann Arbor MI, US
Liu Liu - Ann Arbor MI, US
Longchuan Bai - Ann Arbor MI, US
Donna McEachem - Ann Arbor MI, US
Jeanne Stuckey - Fenton MI, US
Xiaoqin Li - Ann Arbor MI, US
Haibin Zhou - Ann Arbor MI, US
Jianfang Chen - Ann Arbor MI, US
Angelo Aguilar - Ann Arbor MI, US
Jennifer L. Meagher - Plymouth MI, US
Duxin Sun - Ann Arbor MI, US
Chao-Yie Yang - Ann Arbor MI, US
Liu Liu - Ann Arbor MI, US
Longchuan Bai - Ann Arbor MI, US
Donna McEachem - Ann Arbor MI, US
Jeanne Stuckey - Fenton MI, US
Xiaoqin Li - Ann Arbor MI, US
Assignee:
THE REGENTS OF UNIVERSITY OF MICHIGAN - Ann Arbor MI
International Classification:
A61K 51/00, A61K 31/5377, A61K 31/496, C07D 413/14, C07D 403/12, C07D 401/14, C07D 403/10, C07D 405/10, A61P 35/00, A61K 31/5513, C07D 471/04
US Classification:
424 111, 51421018, 5142102, 514218, 5142365, 51425211, 51425304, 51425309, 51425401, 5142541, 540575, 544121, 544357, 544362, 544364, 544372, 544379
Abstract:
Inhibitors of Bcl-2/Bcl-xL and compositions containing the same are disclosed. Methods of using the Bcl-2/Bcl-xL inhibitors in the treatment of diseases and conditions wherein inhibition of Bcl-2/Bcl-xL provides a benefit, like cancers, also are disclosed.
Electromagnetic System And Method
US Patent:
2012003, Feb 9, 2012
Filed:
Aug 15, 2011
Appl. No.:
13/210293
Inventors:
Vishwanath Subramaniam - Westerville OH, US
Joseph West - Richwood OH, US
Jennifer McFerran Brock - Anchorage AK, US
Emily Sequin - Columbus OH, US
Duxin Sun - Ann Arbor MI, US
Peng Zou - Walkersville MD, US
Joseph West - Richwood OH, US
Jennifer McFerran Brock - Anchorage AK, US
Emily Sequin - Columbus OH, US
Duxin Sun - Ann Arbor MI, US
Peng Zou - Walkersville MD, US
Assignee:
THE OHIO STATE UNIVERSITY - Columbus OH
International Classification:
A61B 5/053, A61B 5/05, A61N 2/02
US Classification:
600409, 600547, 600 13, 600425
Abstract:
Differences of electromagnetic (EM) properties between healthy and cancerous tissues allow detection of abnormal conditions occurring in a tissue of an animal, for example, intra-operative cancer detection. By using a time-varying EM field, electrical eddy currents are generated in the tissue sample, and assessed using phase-sensitive detection. In some aspects, a change in phase shift between the voltage in a receiver coil and the voltage in a driver coil provide a direct and immediate indication of differences in EM properties of specimens.
Hsp90 Inhibitors Of Protein-Protein Interaction Hsp90 Chaperone Complexes And Therapeutic Uses Thereof
US Patent:
2010024, Sep 30, 2010
Filed:
Nov 10, 2008
Appl. No.:
12/741430
Inventors:
Duxin Sun - Ann Arbor MI, US
Tao Zhang - Ann Arbor MI, US
Tao Zhang - Ann Arbor MI, US
Assignee:
THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION - Columbus OH
International Classification:
A61K 31/19, C12N 5/02, C07C 59/00, C12Q 1/02
US Classification:
514557, 435375, 562461, 435 29
Abstract:
A novel Hsp90 inhibitor that disrupts protein-protein interaction in a Hsp90 superchaperone complex without blocking ATP binding and methods for treating diseases such as pancreatic cancer are disclosed.
Spiro-Oxindole Mdm2 Antagonists
US Patent:
2013029, Nov 7, 2013
Filed:
Jul 17, 2013
Appl. No.:
13/944587
Inventors:
Shanghai Yu - Ann Arbor MI, US
Wei Sun - , US
Sanjeev Kumar - Ann Arbor MI, US
Duxin Sun - Ann Arbor MI, US
Peng Zou - Ann Arbor MI, US
Donna McEachern - Ann Arbor MI, US
Yujun Zhao - Ann Arbor MI, US
Wei Sun - , US
Sanjeev Kumar - Ann Arbor MI, US
Duxin Sun - Ann Arbor MI, US
Peng Zou - Ann Arbor MI, US
Donna McEachern - Ann Arbor MI, US
Yujun Zhao - Ann Arbor MI, US
International Classification:
C07D 487/10, A61K 31/5377, A61K 31/454, A61K 31/496, A61K 31/407, A61K 45/06
US Classification:
51421021, 548410, 514409, 546 15, 514278, 544230, 51425409, 544 70, 5142352
Abstract:
Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.