DUXIN SUN
Pharmacy in Ann Arbor, MI
License number
Michigan 5304000898
Issued Date
Oct 18, 2011
Expiration Date
Jun 30, 2018
Category
Pharmacy
Type
CS - Research Lab
Address
Address
Ann Arbor, MI 48109
Personal information
See more information about DUXIN SUN at radaris.comName
Address
Phone
3342 Honeysuckle Dr, Ann Arbor, MI 48103
Professional information
Fluorescence Detection System
US Patent:
2009023, Sep 17, 2009
Filed:
Jan 12, 2009
Appl. No.:
12/352408
Inventors:
Edward W. Martin - Delaware OH, US
Ronald X. Xu - Columbus OH, US
Duxin Sun - Ann Arbor MI, US
Stephen P. Povoski - Dublin OH, US
Joseph Pierre Heremans - Upper Arlington OH, US
Robert Lee - Hilliard OH, US
Vish V. Subramaniam - Westerville OH, US
Claudia Turro - Powell OH, US
Ronald X. Xu - Columbus OH, US
Duxin Sun - Ann Arbor MI, US
Stephen P. Povoski - Dublin OH, US
Joseph Pierre Heremans - Upper Arlington OH, US
Robert Lee - Hilliard OH, US
Vish V. Subramaniam - Westerville OH, US
Claudia Turro - Powell OH, US
Assignee:
The Ohio State University Research Foundation - Columbus OH
International Classification:
A61B 6/00, A61K 49/00
US Classification:
600431, 424 96
Abstract:
Exemplary embodiments include systems, methods, and compositions for the intra-operative detection of target tissue. At least one embodiment includes a fluorescence detection instrument that may be used for intra-operative detection of a fluorescent targeting agent, its binding site, and its interaction within cancer tissues. An exemplary embodiment is highly sensitive to the local deposition of fluorescence agents even at a low concentration. In at least one embodiment, the system includes a handheld navigation instrument that is usable to excite, detect, and report the fluorescent deposition of the targeting agent in real-time. In alternative embodiments, the system includes a wearable unit to excite, detect, and visually report the fluorescent deposition of the targeting agent to the user. The wearable unit includes eyewear that allow the user to perform image-guided surgery based on the near real-time fluorescence detection of the fluorescent targeting agent.
Spiro-Oxindole Mdm2 Antagonists
US Patent:
8518984, Aug 27, 2013
Filed:
Nov 12, 2010
Appl. No.:
12/945511
Inventors:
Shaomeng Wang - Saline MI, US
Shanghai Yu - Ann Arbor MI, US
Wei Sun - Ann Arbor MI, US
Sanjeev Kumar - Ann Arbor MI, US
Duxin Sun - Ann Arbor MI, US
Peng Zou - Ann Arbor MI, US
Donna McEachern - Ann Arbor MI, US
Yujun Zhao - Ann Arbor MI, US
Shanghai Yu - Ann Arbor MI, US
Wei Sun - Ann Arbor MI, US
Sanjeev Kumar - Ann Arbor MI, US
Duxin Sun - Ann Arbor MI, US
Peng Zou - Ann Arbor MI, US
Donna McEachern - Ann Arbor MI, US
Yujun Zhao - Ann Arbor MI, US
Assignee:
The Regents of the University of Michigan - Ann Arbor MI
International Classification:
C07D 487/10, A61K 31/4015
US Classification:
514409, 548406
Abstract:
Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.
Bcl-2/Bcl-Xl Inhibitors And Therapeutic Methods Using The Same
US Patent:
2012018, Jul 26, 2012
Filed:
Jan 24, 2012
Appl. No.:
13/356763
Inventors:
Shaomeng Wang - Saline MI, US
Haibin Zhou - Ann Arbor MI, US
Jianfang Chen - Ann Arbor MI, US
Angelo Aguilar - Ann Arbor MI, US
Jennifer L. Meagher - Plymouth MI, US
Duxin Sun - Ann Arbor MI, US
Chao-Yie Yang - Ann Arbor MI, US
Liu Liu - Ann Arbor MI, US
Longchuan Bai - Ann Arbor MI, US
Donna McEachem - Ann Arbor MI, US
Jeanne Stuckey - Fenton MI, US
Xiaoqin Li - Ann Arbor MI, US
Haibin Zhou - Ann Arbor MI, US
Jianfang Chen - Ann Arbor MI, US
Angelo Aguilar - Ann Arbor MI, US
Jennifer L. Meagher - Plymouth MI, US
Duxin Sun - Ann Arbor MI, US
Chao-Yie Yang - Ann Arbor MI, US
Liu Liu - Ann Arbor MI, US
Longchuan Bai - Ann Arbor MI, US
Donna McEachem - Ann Arbor MI, US
Jeanne Stuckey - Fenton MI, US
Xiaoqin Li - Ann Arbor MI, US
Assignee:
THE REGENTS OF UNIVERSITY OF MICHIGAN - Ann Arbor MI
International Classification:
A61K 51/00, A61K 31/5377, A61K 31/496, C07D 413/14, C07D 403/12, C07D 401/14, C07D 403/10, C07D 405/10, A61P 35/00, A61K 31/5513, C07D 471/04
US Classification:
424 111, 51421018, 5142102, 514218, 5142365, 51425211, 51425304, 51425309, 51425401, 5142541, 540575, 544121, 544357, 544362, 544364, 544372, 544379
Abstract:
Inhibitors of Bcl-2/Bcl-xL and compositions containing the same are disclosed. Methods of using the Bcl-2/Bcl-xL inhibitors in the treatment of diseases and conditions wherein inhibition of Bcl-2/Bcl-xL provides a benefit, like cancers, also are disclosed.
Electromagnetic System And Method
US Patent:
2012003, Feb 9, 2012
Filed:
Aug 15, 2011
Appl. No.:
13/210293
Inventors:
Vishwanath Subramaniam - Westerville OH, US
Joseph West - Richwood OH, US
Jennifer McFerran Brock - Anchorage AK, US
Emily Sequin - Columbus OH, US
Duxin Sun - Ann Arbor MI, US
Peng Zou - Walkersville MD, US
Joseph West - Richwood OH, US
Jennifer McFerran Brock - Anchorage AK, US
Emily Sequin - Columbus OH, US
Duxin Sun - Ann Arbor MI, US
Peng Zou - Walkersville MD, US
Assignee:
THE OHIO STATE UNIVERSITY - Columbus OH
International Classification:
A61B 5/053, A61B 5/05, A61N 2/02
US Classification:
600409, 600547, 600 13, 600425
Abstract:
Differences of electromagnetic (EM) properties between healthy and cancerous tissues allow detection of abnormal conditions occurring in a tissue of an animal, for example, intra-operative cancer detection. By using a time-varying EM field, electrical eddy currents are generated in the tissue sample, and assessed using phase-sensitive detection. In some aspects, a change in phase shift between the voltage in a receiver coil and the voltage in a driver coil provide a direct and immediate indication of differences in EM properties of specimens.
Hsp90 Inhibitors Of Protein-Protein Interaction Hsp90 Chaperone Complexes And Therapeutic Uses Thereof
US Patent:
2010024, Sep 30, 2010
Filed:
Nov 10, 2008
Appl. No.:
12/741430
Inventors:
Duxin Sun - Ann Arbor MI, US
Tao Zhang - Ann Arbor MI, US
Tao Zhang - Ann Arbor MI, US
Assignee:
THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION - Columbus OH
International Classification:
A61K 31/19, C12N 5/02, C07C 59/00, C12Q 1/02
US Classification:
514557, 435375, 562461, 435 29
Abstract:
A novel Hsp90 inhibitor that disrupts protein-protein interaction in a Hsp90 superchaperone complex without blocking ATP binding and methods for treating diseases such as pancreatic cancer are disclosed.
Spiro-Oxindole Mdm2 Antagonists
US Patent:
2013029, Nov 7, 2013
Filed:
Jul 17, 2013
Appl. No.:
13/944587
Inventors:
Shanghai Yu - Ann Arbor MI, US
Wei Sun - , US
Sanjeev Kumar - Ann Arbor MI, US
Duxin Sun - Ann Arbor MI, US
Peng Zou - Ann Arbor MI, US
Donna McEachern - Ann Arbor MI, US
Yujun Zhao - Ann Arbor MI, US
Wei Sun - , US
Sanjeev Kumar - Ann Arbor MI, US
Duxin Sun - Ann Arbor MI, US
Peng Zou - Ann Arbor MI, US
Donna McEachern - Ann Arbor MI, US
Yujun Zhao - Ann Arbor MI, US
International Classification:
C07D 487/10, A61K 31/5377, A61K 31/454, A61K 31/496, A61K 31/407, A61K 45/06
US Classification:
51421021, 548410, 514409, 546 15, 514278, 544230, 51425409, 544 70, 5142352
Abstract:
Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.