DOUGLAS W LOSORDO, MD
Osteopathic Medicine at Cambridge St, Boston, MA
License number
Massachusetts 53385
Category
Osteopathic Medicine
Type
Cardiovascular Disease
Address
Address
736 Cambridge St, Boston, MA 02135
Phone
(617) 789-3149
(617) 789-5029 (Fax)
(617) 789-5029 (Fax)
Professional information
Morphogen Compositions And Methods Of Use Thereof To Treat Heart Disorders
US Patent:
2007017, Jul 26, 2007
Filed:
Jan 24, 2006
Appl. No.:
11/339808
Inventors:
Douglas Losordo - Boston MA, US
International Classification:
A61K 48/00, A61K 38/17, A61F 2/02
US Classification:
514044000, 424423000, 514012000
Abstract:
Disclosed are compositions and methods for preventing, treating, or reducing symptoms associated with a myocardial or related disorder such as an infarction. In one embodiment, the method includes administering a therapeutically effective amount of a nucleic acid encoding at least one morphogen; or an effective fragment thereof. Preferred morphogens include the human Sonic Hedghog (Shh), human Desert Hedgehog (Dhh), and human Indian Hedgehog (Ihh) proteins. The methods can be used alone or in combination with other methods involving administration of an angiogenic protein, hematopoietic protein, or endothelial precursor cells (EPCs).