DOUGLAS SMITH, MD
Medical Practice in Ann Arbor, MI
License number
Michigan 4301088906
Category
Medical Practice
Type
Blood Banking & Transfusion Medicine
License number
Michigan 4301088906
Category
Medical Practice
Type
Anatomic Pathology & Clinical Pathology
Address
Address
1500 Floor University Hospital Recp Pathology, Ann Arbor, MI 48109
Phone
(800) 862-7284
(734) 936-2047
(734) 936-2047
Professional information
Douglas Henderson Smith, Ann Arbor MI
Specialties:
Internal Medicine, Anatomic Pathology & Clinical Pathology, Blood Banking & Transfusion Medicine
Work:
University of Michigan Medical School
1500 E Medical Center Dr, Ann Arbor, MI 48109
1500 E Medical Center Dr, Ann Arbor, MI 48109
Education:
(1949)
Dr. Douglas Smith, Ann Arbor MI - MD (Doctor of Medicine)
Specialties:
Blood Banking & Transfusion Medicine
Address:
1500 E Medical Center Dr SUITE 2ND, Ann Arbor 48109
(800) 862-7284 (Phone)
(800) 862-7284 (Phone)
Certifications:
Anatomic & Clinical Pathology, 1985, Blood Bank & Transfusion Medicine, 1992
Awards:
Healthgrades Honor Roll
Languages:
English
Hospitals:
1500 E Medical Center Dr SUITE 2ND, Ann Arbor 48109
University of Michigan Health System
1500 East Medical Center Dr SPC 5474, Ann Arbor 48109
University of Michigan Health System
1500 East Medical Center Dr SPC 5474, Ann Arbor 48109
Education:
Medical School
University Of Iowa
Spectrum Health-Blodgett Hospital
St Paul-Ramsey Med Ctr
University Of Minnesota
University Of Iowa
Spectrum Health-Blodgett Hospital
St Paul-Ramsey Med Ctr
University Of Minnesota
Human Lineage Committed Cell Composition With Enhanced Proliferative Potential, Biological Effector Function, Or Both; Methods For Obtaining Same; And Their Uses
US Patent:
6835566, Dec 28, 2004
Filed:
Jun 29, 2001
Appl. No.:
09/893470
Inventors:
Alan K. Smith - Saline MI
Douglas M. Smith - Ann Arbor MI
Ramkumar K. Mandalam - Westland MI
Douglas M. Smith - Ann Arbor MI
Ramkumar K. Mandalam - Westland MI
Assignee:
Aastrom Biosciences, Inc. - Ann Arbor MI
International Classification:
C12N 506
US Classification:
435355, 435 2, 435371, 435372, 4353721, 435377, 435400, 435401
Abstract:
A method for obtaining lineage committed human cells imbued with enhanced proliferative potential, biological function, or both, comprising culturing lineage committed human cells under physiologically acceptable liquid culture conditions, where the liquid culture medium is replaced at a rate and for a time sufficient to obtain the human lineage committed cells imbued with enhanced proliferative potential, biological function, or both; and isolating the cultured cells.
Human Lineage Committed Cell Composition With Enhanced Proliferative Potential, Biological Effector Function, Or Both: Methods For Obtaining Same; And Their Uses
US Patent:
2006009, May 4, 2006
Filed:
Dec 7, 2005
Appl. No.:
11/295596
Inventors:
Alan Smith - Saline MI, US
Douglas Smith - Ann Arbor MI, US
Ramkumar Mandalam - Westland MI, US
Douglas Smith - Ann Arbor MI, US
Ramkumar Mandalam - Westland MI, US
Assignee:
AASTROM BIOSCIENCES, INC. - Ann Arbor MI
International Classification:
A61K 35/14, C12N 5/08
US Classification:
424093100, 435372000
Abstract:
A method for obtaining lineage committed human cells imbued with enhanced proliferative potential, biological function, or both, comprising culturing lineage committed human cells under physiologically acceptable liquid culture conditions, where the liquid culture medium is replaced at a rate and for a time sufficient to obtain the human lineage committed cells imbued with enhanced proliferative potential, biological function, or both; and isolating the cultured cells.
Human Lineage Committed Cell Composition With Enhanced Proliferative Potential, Biological Effector Function, Or Both; Methods For Obtaining Same; And Their Uses
US Patent:
2002003, Mar 21, 2002
Filed:
Feb 23, 1998
Appl. No.:
09/027671
Inventors:
ALAN K. SMITH - SALINE MI, US
DOUGLAS M. SMITH - ANN ARBOR MI, US
RAMKUMAR MANDALAM - WESTLAND MI, US
DOUGLAS M. SMITH - ANN ARBOR MI, US
RAMKUMAR MANDALAM - WESTLAND MI, US
International Classification:
C12N005/02, C12N005/00, C12N005/08, A01N065/00, A01N063/00
US Classification:
435/366000, 435/372000, 435/372300, 435/374000, 435/375000, 435/377000, 435/384000, 435/385000, 435/368000
Abstract:
A method for obtaining lineage committed human cells imbued with enhanced proliferative potential, biological function, or both, comprising culturing lineage committed human cells under physiologically acceptable liquid culture conditions, where the liquid culture medium is replaced at a rate and for a time sufficient to obtain the human lineage committed cells imbued with enhanced proliferative potential, biological function, or both; and isolating the cultured cells.
Human Lineage Committed Cell Composition With Enhanced Proliferative Potential, Biological Effector Function, Or Both; Methods For Obtaining Same; And Their Uses
US Patent:
2004006, Apr 1, 2004
Filed:
Sep 24, 2003
Appl. No.:
10/668214
Inventors:
Alan Smith - Saline MI, US
Douglas Smith - Ann Arbor MI, US
Ramkumar Mandalam - Westland MI, US
Douglas Smith - Ann Arbor MI, US
Ramkumar Mandalam - Westland MI, US
Assignee:
AASTROM BIOSCIENCES, INC. - Ann Arbor MI
International Classification:
A61K045/00
US Classification:
424/093700
Abstract:
A method for obtaining lineage committed human cells imbued with enhanced proliferative potential, biological function, or both, comprising culturing lineage committed human cells under physiologically acceptable liquid culture conditions, where the liquid culture medium is replaced at a rate and for a time sufficient to obtain the human lineage committed cells imbued with enhanced proliferative potential, biological function, or both; and isolating the cultured cells.
Mixed Cell Populations For Tissue Repair And Separation Technique For Cell Processing
US Patent:
2013020, Aug 15, 2013
Filed:
Mar 4, 2013
Appl. No.:
13/784066
Inventors:
Kristin Goltry - Milan MI, US
Douglas M. Smith - Ann Arbor MI, US
Jonathan A. Rowley - Ann Arbor MI, US
Naia Venturi - Ypsilanti MI, US
Douglas M. Smith - Ann Arbor MI, US
Jonathan A. Rowley - Ann Arbor MI, US
Naia Venturi - Ypsilanti MI, US
Assignee:
Aastrom Biosciences, Inc. - Ann Arbor MI
International Classification:
A61K 35/28
US Classification:
424 937, 435325, 435378
Abstract:
The present invention provides a fluid exchange cell culture technique and tissue repair cells (TRCs) made by these methods, as well as methods using these cells. The method includes a new wash step which increases the tissue repair properties of the TRCs of the invention. This wash step allows for the production of TRC populations with greater tissue repair and anti-inflammatory capabilities. Embodiments of the present invention include a post-culture process for cultured cells that preferably includes the steps of: a wash process for removing unwanted residual culture components, a volume reduction process, and a harvesting process to remove cultured cells. Preferably, all these steps are performed within a aseptically closed cell culture chamber by implementing a separation method that minimizes mechanical disruption of the cells and is simple to automate. The harvested cells may then be concentrated to a final volume for the intended use. In such embodiments, the final composition is a substantially purified and concentrated cell mixture suspended in a physiologic solution suitable for immediate use in humans without further washing, volume reduction, or processing. Embodiments are also applicable to harvesting (and/or washing) particles within a liquid or solution within a chamber.
Mixed Cell Populations For Tissue Repair And Separation Technique For Cell Processing
US Patent:
8158122, Apr 17, 2012
Filed:
Dec 7, 2010
Appl. No.:
12/962355
Inventors:
Brian Hampson - Canton MI, US
Kristin Goltry - Milan MI, US
Douglas M. Smith - Ann Arbor MI, US
Jonathan A. Rowley - Ann Arbor MI, US
Naia Venturi - Ypsilanti MI, US
Kristin Goltry - Milan MI, US
Douglas M. Smith - Ann Arbor MI, US
Jonathan A. Rowley - Ann Arbor MI, US
Naia Venturi - Ypsilanti MI, US
Assignee:
Aastrom Biosciences Inc. - Ann Arbor MI
International Classification:
C12N 5/0775, C12N 5/074, C12N 5/0789
US Classification:
424 937, 435347
Abstract:
The present invention provides a fluid exchange cell culture technique and tissue repair cells (TRCs) made by these methods, as well as methods using these cells. The method includes a new wash step which increases the tissue repair properties of the TRCs of the invention. This wash step allows for the production of TRC populations with greater tissue repair and anti-inflammatory capabilities. Embodiments of the present invention include a post-culture process for cultured cells that preferably includes the steps of: a wash process for removing unwanted residual culture components, a volume reduction process, and a harvesting process to remove cultured cells. Preferably, all these steps are performed within a aseptically closed cell culture chamber by implementing a separation method that minimizes mechanical disruption of the cells and is simple to automate. The harvested cells may then be concentrated to a final volume for the intended use. In such embodiments, the final composition is a substantially purified and concentrated cell mixture suspended in a physiologic solution suitable for immediate use in humans without further washing, volume reduction, or processing.
Mixed Cell Populations For Tissue Repair And Separation Technique For Cell Processing
US Patent:
8394631, Mar 12, 2013
Filed:
Dec 7, 2010
Appl. No.:
12/962378
Inventors:
Brian Hampson - Canton MI, US
Kristin Goltry - Milan MI, US
Douglas M. Smith - Ann Arbor MI, US
Jonathan A. Rowley - Ann Arbor MI, US
Naia Venturi - Ypsilanti MI, US
Kristin Goltry - Milan MI, US
Douglas M. Smith - Ann Arbor MI, US
Jonathan A. Rowley - Ann Arbor MI, US
Naia Venturi - Ypsilanti MI, US
Assignee:
Aastrom Biosciences, Inc. - Ann Arbor MI
International Classification:
C12N 5/07
US Classification:
435378, 435380
Abstract:
The present invention provides a fluid exchange cell culture technique and tissue repair cells (TRCs) made by these methods, as well as methods using these cells. The method includes a new wash step which increases the tissue repair properties of the TRCs of the invention. This wash step allows for the production of TRC populations with greater tissue repair and anti-inflammatory capabilities. Embodiments of the present invention include a post-culture process for cultured cells that preferably includes the steps of: a wash process for removing unwanted residual culture components, a volume reduction process, and a harvesting process to remove cultured cells. Preferably, all these steps are performed within a aseptically closed cell culture chamber by implementing a separation method that minimizes mechanical disruption of the cells and is simple to automate. The harvested cells may then be concentrated to a final volume for the intended use. In such embodiments, the final composition is a substantially purified and concentrated cell mixture suspended in a physiologic solution suitable for immediate use in humans without further washing, volume reduction, or processing.
Immunogenic Compositions Comprising Nanoemulsion And Hepatitis B Virus Immunogen And Methods Of Using The Same
US Patent:
2012025, Oct 11, 2012
Filed:
Jun 4, 2012
Appl. No.:
13/487925
Inventors:
Douglas Smith - Ann Arbor MI, US
Paul E. Makidon - Webberville MI, US
Paul E. Makidon - Webberville MI, US
Assignee:
THE REGENTS OF THE UNIVERSITY OF MICHIGAN - Ann Arbor MI
International Classification:
A61K 39/29, A61P 31/12
US Classification:
4242271
Abstract:
The invention provides immunogenic compositions and methods of using the same to induce immune responses (e.g., humoral, mucosal, and/or cell-mediated immune responses) against Hepatitis B virus (HBV)). Compositions and methods of the invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination (e.g., of patient populations at risk for acute and/or chronic HBV infection))) and research applications.
Medical Practice licenses in Michigan
RACHEL R OSBORN, Medical Practice, 1500 Floor Cs Mott Childrens Hospital RM 525, Ann Arbor, MI 48109
KATHLEEN R CHO, Medical Practice, 1500 Floor University Hospital Recp Pathology, Ann Arbor, MI 48109