Inventors:
William Paul Peters - Fernandina Beach FL, US
Brian Huber - Durham NC, US
Douglas Scott Tyler - Hillsborough NC, US
Assignee:
ADHEREX TECHNOLOGIES, INC. - Ottawa
DEPARTMENT OF VETERANS AFFAIRS - Washington DC
International Classification:
A61K 38/12, A61K 31/197, A61P 35/00
Abstract:
Improved methods for treating cancer which employ combinations comprising cadherin antagonists with certain anticancer agents or treatments are provided. The methods of the invention involve the administration of cadherin antagonist before, concurrent with, or after, administration of an anticancer agent or treatment and provide unexpectedly improved therapeutic benefit in the treatment of tumors growing in vivo.