Inventors:
Balaraman Kalyanaraman - Wauwatosa WI, US
Joy Joseph - New Berlin WI, US
Kathleen Marie Schmainda - Elm Grove WI, US
Douglas Edward Prah - Milwaukee WI, US
Marcos Lopez - Wauwatosa WI, US
Micael J. Hardy - La Seyne sure mer, FR
Assignee:
Medical College of Wisconsin Research Foundation - Milwaukee WI
International Classification:
A61K 49/06, C07F 9/28
US Classification:
424 933, 424 93, 424 936, 556 20
Abstract:
A system and method for acquiring MR imaging data from a subject includes administering positively-charged nitroxides or gadolinium chelates for in vivo mitochondrial labeling, acquiring MR imaging data from the subject, and reconstructing an image of the subject having enhanced contrast in areas including metabolic and/or mitotic activity.