DOUGLAS E COLE
Nursing at Flax Ct, San Diego, CA
License number
Florida 1013721
Issued Date
Apr 29, 1991
Effective Date
Jan 1, 1901
Expiration Date
Jul 31, 1997
Category
Health Care
Type
Licensed Practical Nurse
Address
Address
1019 Flax Ct, San Diego, CA 92154
Professional information
Trans Cyclopentanyl Deazaadenyl Analogs Useful As Immunosuppressants
US Patent:
5916892, Jun 29, 1999
Filed:
Nov 20, 1997
Appl. No.:
8/975086
Inventors:
David R. Borcherding - Loveland OH
Carl K. Edwards - Superior CO
Ronald E. Esser - Berkeley Heights NJ
Douglas L. Cole - San Diego CA
Carl K. Edwards - Superior CO
Ronald E. Esser - Berkeley Heights NJ
Douglas L. Cole - San Diego CA
Assignee:
Hoechst Marion Roussel, Inc. - Bridgewater NJ
International Classification:
C07D47316, C07D47334, C07D47332, A61K 31505
US Classification:
514258
Abstract:
This invention relates to Trans cyclopentanyl purine analogs of the formula (1) ##STR1## wherein the substituent in the 3-position on the cyclopentanyl ring is in the Trans configuration relative to the bicyclic substituent,
Y. sub. 3, Y. sub. 5 and Y. sub. 9 are each nitrogen and Y. sub. 7 and Y. sub. 8 are a CH group,
R is a hydrogen, a C. sub. 1 -C. sub. 7 alkyl acyl or aryl acyl,
Q is NH. sub. 2, halogen or hydrogen,
Z is hydrogen, halogen, or NH. sub. 2 ;
or a pharmaceutically-acceptable salt thereof, and to their use as immunosuppressants.
Protecting Group For Synthesizing Oligonucleotide Analogs
US Patent:
5760209, Jun 2, 1998
Filed:
Mar 3, 1997
Appl. No.:
8/811232
Inventors:
Zacharia S. Cheruvallath - San Diego CA
Daniel C. Capaldi - San Diego CA
Vasulinga T. Ravikumar - Carlsbad CA
Douglas L. Cole - San Diego CA
Daniel C. Capaldi - San Diego CA
Vasulinga T. Ravikumar - Carlsbad CA
Douglas L. Cole - San Diego CA
Assignee:
ISIS Pharmaceuticals, Inc. - Carlsbad CA
International Classification:
C07H 102, C07H 2104, C07H 2102
US Classification:
536 2534
Abstract:
Nucleoside analog phosphoramidites are provided in which the 3'-hydroxyl group is protected with an 2-N-amidoethyl group. The 2-N-amidoethyl protected nucleoside analogs are useful in the synthesis of a wide variety of oligonucleotide analogs. Coupling yields with the protected phosphoramidites in solution or solid phase oligonucleotide analog synthesis are high and the 2-N-amidoethyl group can be removed easily under standard conditions.
Trans Cyclopentanyl Purine Analogs Useful As Immunosuppressants
US Patent:
5723466, Mar 3, 1998
Filed:
Jun 7, 1995
Appl. No.:
8/485263
Inventors:
David R. Borcherding - Loveland OH
Carl K. Edwards - Superior CO
Ronald E. Esser - Berkeley Heights NJ
Douglas L. Cole - San Diego CA
Carl K. Edwards - Superior CO
Ronald E. Esser - Berkeley Heights NJ
Douglas L. Cole - San Diego CA
Assignee:
Hoechst Marion Roussel, Inc. - Cincinnati OH
International Classification:
C07D48704, A61K 31505
US Classification:
514258
Abstract:
This invention relates to Trans cyclopentanyl purine analogs of the formula (1) ##STR1## wherein the substituent in the 3-position on the cyclopentanyl ring is in the Trans configuration relative to the bicyclic substituent,
Y. sub. 3, Y. sub. 5 and Y. sub. 9 are each nitrogen and Y. sub. 7 and Y. sub. 8 are a CH group,
R is a C. sub. 1 -C. sub. 7 alkyl acyl or aryl acyl,
Q is NH. sub. 2, halogen or hydrogen,
Z is hydrogen, halogen, or NH. sub. 2 ;
or a pharmaceutically-acceptable salt thereof, and to their use as immunosuppressants.
Method For The Synthesis Of Nucleotide Or Oligonucleotide Phosphoramidites
US Patent:
5955600, Sep 21, 1999
Filed:
Dec 27, 1996
Appl. No.:
8/775019
Inventors:
Richard H. Griffey - Vista CA
Douglas L. Cole - San Diego CA
Vasulinga Ravikumar - Carlsbad CA
Douglas L. Cole - San Diego CA
Vasulinga Ravikumar - Carlsbad CA
Assignee:
Isis Pharmaceuticals, Inc. - Carlsbad CA
International Classification:
C07H 2102, C07H 2104
US Classification:
536 2534
Abstract:
This invention presents novel methods for recovery of phosphoramidites from the waste products of oligonucleotide synthesis. The methods include reacting a tribromophenoxydichlorophosphorane with a H-phosphonate in the presence of an amine.
Method Of Synthesizing Phosphorothioate Oligonucleotides
US Patent:
2002012, Sep 12, 2002
Filed:
Feb 6, 2002
Appl. No.:
10/068604
Inventors:
Douglas Cole - San Diego CA, US
Vasulinga Ravikumar - Carlsbad CA, US
Vasulinga Ravikumar - Carlsbad CA, US
Assignee:
ISIS Pharmaceuticals, Inc.
International Classification:
C07H021/04, C07H021/02
US Classification:
536/025340
Abstract:
This invention presents novel methods for synthesizing phosphorothioate oligonucleotides, using support-bound phosphoramidites. Novel intermediates useful in the methods are also provided.
Trans Cyclopentanyl Purine Analogs Useful As Immunosuppressants
US Patent:
5817672, Oct 6, 1998
Filed:
Jun 7, 1995
Appl. No.:
8/477344
Inventors:
David R. Borcherding - Loveland OH
Carl K. Edwards - Superior CO
Ronald E. Esser - Berkeley Heights NJ
Douglas L. Cole - San Diego CA
Carl K. Edwards - Superior CO
Ronald E. Esser - Berkeley Heights NJ
Douglas L. Cole - San Diego CA
Assignee:
Hoechst Marion Roussel, Inc. - Cincinnati OH
International Classification:
C07D47334, C07D47316, C07D47104, A61K 3144
US Classification:
514303
Abstract:
This invention relates to novel Trans cyclopentanyl purine analogs of the formula (1) ##STR1## wherein the substituent in the 3-position on the cyclopentanyl ring is in the Trans configuration relative to the bicyclic substituent, Y. sub. 3 and Y. sub. 8 are CH, Y. sub. 5, Y. sub. 7 and Y. sub. 9 are each independently nitrogen,
R is a hydrogen, a C. sub. 1 -C. sub. 7 alkyl acyl or aryl acyl,
Q is NH. sub. 2, halogen or hydrogen,
Z is hydrogen, halogen, or NH. sub. 2 ;
or a pharmaceutically-acceptable salt thereof, and to their use as immunosuppressants.
Trans Cyclopentanyl Deazaadenyl Analogs Useful As Immunosuppressants
US Patent:
5905085, May 18, 1999
Filed:
Nov 20, 1997
Appl. No.:
8/975552
Inventors:
David R. Borcherding - Loveland OH
Carl K. Edwards - Superior CO
Ronald E. Esser - Berkeley Heights NJ
Douglas L. Cole - San Diego CA
Carl K. Edwards - Superior CO
Ronald E. Esser - Berkeley Heights NJ
Douglas L. Cole - San Diego CA
Assignee:
Hoechst Marion Roussel, Inc. - Bridgewater NJ
International Classification:
C07D471/04;473/16
US Classification:
514303
Abstract:
This invention relates to novel Trans cyclopentanyl purine analogs of the formula (1) ##STR1## wherein the substituent in the 3-position on the cyclopentanyl ring is in the Trans configuration relative to the bicyclic substituent,
Y. sub. 3 and Y. sub. 8 are CH, Y. sub. 5, Y. sub. 7 and Y. sub. 9 are each independently nitrogen,
R is a hydrogen, a C. sub. 1 -C. sub. 7 alkyl acyl or aryl acyl,
Q is NH. sub. 2, halogen or hydrogen,
Z is hydrogen, halogen, or NH. sub. 2 ;
or a pharmaceutically-acceptable salt thereof, and to their use as immunosuppressants.
Use Of Carbocation Scavenger During Oligonucleotide Synthesis
US Patent:
5714597, Feb 3, 1998
Filed:
Mar 8, 1996
Appl. No.:
8/613036
Inventors:
Vasulinga Ravikumar - Carlsbad CA
Mark Andrade - Carlsbad CA
Dennis Mulvey - Conroe TX
Douglas L. Cole - San Diego CA
Mark Andrade - Carlsbad CA
Dennis Mulvey - Conroe TX
Douglas L. Cole - San Diego CA
Assignee:
ISIS Pharmaceuticals, Inc. - Carlsbad CA
International Classification:
C07H 100, C07H 2100, C07H 2102, C07H 2104
US Classification:
536 2531
Abstract:
During the synthesis of oligonucleotides and phosphate linked oligomers, a carbocation scavenging agent is employed to increase the overall yield. The carbocation scavenging agent is used in conjunction with an acidic solution employed during the deprotection step.
Process For The Synthesis Of Oligomeric Compounds
US Patent:
7041816, May 9, 2006
Filed:
Jan 20, 2004
Appl. No.:
10/760940
Inventors:
Vasulinga T. Ravikumar - Carlsbad CA, US
Muthiah Manoharan - Carlsbad CA, US
Daniel C. Capaldi - San Diego CA, US
Achim Krotz - San Diego CA, US
Douglas L. Cole - San Diego CA, US
Andrei Guzaev - Carlsbad CA, US
Muthiah Manoharan - Carlsbad CA, US
Daniel C. Capaldi - San Diego CA, US
Achim Krotz - San Diego CA, US
Douglas L. Cole - San Diego CA, US
Andrei Guzaev - Carlsbad CA, US
Assignee:
ISIS Pharmaceuticals, Inc. - Carlsbad CA
International Classification:
C07H 21/00
US Classification:
536 2531, 536 231, 536 243, 536 245, 536 2533, 536 2534
Abstract:
Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
Synthesis Of Sulfurized Oligonucleotides
US Patent:
7227015, Jun 5, 2007
Filed:
Jan 10, 2001
Appl. No.:
10/181200
Inventors:
Douglas L. Cole - San Diego CA, US
Vasulinga T. Ravikumar - Carlsbad CA, US
Zacharia S. Cheruvallath - San Diego CA, US
Vasulinga T. Ravikumar - Carlsbad CA, US
Zacharia S. Cheruvallath - San Diego CA, US
Assignee:
ISIS Pharmaceuticals, Inc. - Carlsbad CA
International Classification:
C07H 21/00
US Classification:
536 253, 536 2533, 536 2534, 568 22
Abstract:
Methods for the formation of sulfurized oligonucleotides are provided. The methods allow for the formation of phosphorothioate linkages in the oligonucleotides or derivatives, without the need for complex solvent mixtures and repeated washing or solvent changes. Oligonucleotides having from about 8, and up to about 50, nucleotides can be sulfurized according to the methods of the invention with higher yields than have been previously reported.