Inventors:
Fred de Sauvage - Foster City CA, US
Dorothy French - San Carlos CA, US
Lino Gonzalez - Menlo Park CA, US
Asja Praetor - Singapore, SG
Weilan Ye - Foster City CA, US
Katherin E. Combs - Spring TX, US
Zhiyong Ding - Longmont CO, US
Allison Anne Byers Horner - Dickinson TX, US
Erin Marie Massey - Conroe TX, US
Charles Montgomery - Jay OK, US
Laurie Jeanette Minze - Katy TX, US
Carolina Rangel - Houston TX, US
Tracy Ellen Willis Sevaux - Conroe TX, US
Mary Jean Sparks - Magnolia TX, US
Joy Anne Stala - The Woodlands TX, US
Peter Vogel - The Woodlands TX, US
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
A61K 39/395, G01N 33/00, C12N 5/10, C07K 16/18, A61P 27/00, A61P 25/00, A61P 25/18, A61P 25/22, A61P 37/00, A61P 13/12, A61P 3/00, A61P 19/00, A61P 9/00, A61P 35/00, A61P 41/00, A61P 3/10
US Classification:
4241581, 800 3, 435325, 435352, 5303871
Abstract:
The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO194, PRO220, PRO241, PRO284, PRO331, PRO354, PRO355, PRO533, PRO541, PRO725, PRO937, PRO1014, PRO1120, PRO1182, PRO1325, PRO1382, PRO1410, PRO1555, PRO1556, PRO1760, PRO1787, PRO1868, PRO4326, PRO4332, PRO4346, PRO4400, PRO6003, PRO6094, PRO6244, PRO9820, PRO9828, PRO10274, PRO16090, PRO19644, PRO21340, PRO92165, PRO85143, PRO1124, PRO1026 or PRO23370 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.