Inventors:
Judith Healy - Lexington MA, US
Markus Kurz - Newton MA, US
Thomas McCauley - Cambridge MA, US
Kristin Thompson - Arlington MA, US
Charles Wilson - Concord MA, US
Dorothy Margolskee - Upper Montclair NJ, US
International Classification:
A61K 48/00, A61K 9/14
Abstract:
Materials and methods are provided to modulate, in a controlled manner, the pharmacokinetic and biodistribution properties of nucleic acid aptamers, and to enhance their safety and efficacy properties as therapeutic agents.