Inventors:
Dennis L. Kasper - Newton Center MA
Dori F. Zaleznik - Newton Highlands MA
Robert W. Finberg - Roslindale MA
Assignee:
The Brigham and Women's Hospital, Inc. - Boston MA
International Classification:
C12N 518, C12P 2100
Abstract:
A method of protecting a mammal against a pathogenic bacterium by administering a soluble suppressor T-cell factor derived from a mammal that has been immunized with the bacterium or an antigenic surface fragment of the bacterium. Also disclosed are a hybrid cell fusion of an immunized suppressor T cell, methods of making such cells, and method of producing soluble suppressor T-cell factors.