Inventors:
Thomas B. Nutman - Chevy Chase MD, US
Doran Fink - Silver Spring MD, US
Joseph Kubofcik - Catonsville MD, US
Peter D. Burbelo - Washington DC, US
Assignee:
The United States of America, as represented by the Secretary, Department of Health and Human Serv - Bethesda MA
International Classification:
G01N 33/68
US Classification:
4242651, 530350, 536 235, 514 44 R, 435 772, 4353201, 435365
Abstract:
The polynucleotide encoding the antigen Wb123 from the filarial nematode , the major causative organism of lymphatic filariasis is provided, along with the polypeptide encoded by the polynucleotide. Methods for making the WM23 antigen, recombinant vectors encoding the Wb123 polynucleotide, and methods of detection of the Wb123 antigen through luciferase immunprecipitation, ELISA and other detection systems are also provided.