Inventors:
Donna M. Ambrosino - Jamaica Plain MA, US
Gregory J. Babcock - Marlborough MA, US
Teresa Broering - Brookline MA, US
Susan Sloan - Watertown MA, US
Assignee:
University of Massachusetts - Boston MA
International Classification:
A61K 39/00, A61K 39/42, A61K 39/395, C07K 16/00, C07K 16/08, C07K 16/10, C12P 21/08
US Classification:
4241491, 4241391, 4241411, 4241421, 4241471, 4241591, 4241611, 5303871, 5303879, 5303881, 53038815, 5303883, 5303911, 5303913, 5303917
Abstract:
Isolated human monoclonal antibodies which bind to hepatitis C virus (HCV), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e. g. , a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.