Inventors:
Raj K. Gupta - Walkersville MD, US
Apurba K. Bhattacharjee - Silver Spring MD, US
Donna Ma Lee - Potomac MD, US
Assignee:
The United States of America as represented by the Secretary of the Army - Washington DC
International Classification:
A01N 25/08
US Classification:
424411, 424 47, 424 59, 424403, 424412, 424413, 424414, 424415, 424416, 514622, 514678, 514919
Abstract:
Disclosed herein is a pharmacophore model for arthropod repellent activity and methods of making and using thereof. The pharmacophore comprises two hydrophobic aliphatic functions, one aromatic function and one hydrogen bond acceptor function. The pharmacophore model was made using a test set of arthropod repellent compounds. Also disclosed are arthropod repellent compounds identified by screening databases with the pharmacophore model. Also disclosed are methods of repelling arthropods from a surface or area. Compositions and formulations comprising the compounds of the present invention as well as objects having the compounds of the present invention are disclosed.