Inventors:
Wei Xu - Danville CA, US
Lynne Canne Bannen - Pacifica CA, US
Samuel Brown - San Carlos CA, US
Erick Co - Redwood City CA, US
John Nuss - Danville CA, US
Moon Kim - Palo Alto CA, US
Rhett Klein - San francisco CA, US
Donna Lee - San Jose CA, US
Amy Tsuhako - Milpitas CA, US
Morrison Mac - San Francisco CA, US
Jason Parks - Sacramento CA, US
Zhaoyang Wen - San Francisco CA, US
Wei Cheng - San Jose CA, US
International Classification:
A61K 31/55, A61K 31/454, C07D 403/14
US Classification:
514217090, 514322000, 540603000, 546199000, 546201000
Abstract:
The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides oxindole derivatives which inhibit, regulate and/or modulate kinase receptor, particularly VEGF receptor 2 (Flk-1/KDR), FGFR1, and PDGFR (alpha and beta), signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.