DR. DONN M DENNIS, MD
Anesthesiologist Assistant at Archer Rd, Gainesville, FL

2005023, Oct 20, 2005

Apr 1, 2005

11/097647

Richard Melker - Gainesville FL, US
Donn Dennis - Gainesville FL, US
Laszlo Prokai - Gainesville FL, US

A61M011/00

436056000

The present invention includes systems and methods for monitoring therapeutic drug concentration in blood by detecting markers, such as odors, upon exhalation by a patient after the drug is taken, wherein such markers result either directly from the drug itself or from an additive combined with the drug. In the case of olfactory markers, the invention preferably utilizes electronic sensor technology, such as the commercial devices referred to as “artificial” or “electronic” noses or tongues, to non-invasively monitor drug levels in blood. The invention further includes a reporting system capable of tracking drug concentrations in blood (remote or proximate locations) and providing the necessary alerts with regarding to ineffective or toxic drug dosages in a patient.

6638537, Oct 28, 2003

Aug 8, 2001

09/924290

Donn M. Dennis - Gainesville FL
Nikolaus Gravenstein - Gainesville FL
Jerome H. Modell - Gainesville FL
Timothy E. Morey - Gainesville FL
Dinesh Shah - Gainesville FL

University of Florida - Gainesville FL

A61K 950

424502, 424400, 424484, 424486, 424489, 424501, 424500

A microemulsion delivery system for water insoluble or sparingly water soluble drugs that comprises a long polymer chain surfactant component and a short fatty acid surfactant component, with the amount of each being selected to provide stable microemulsion or micellar systems.

2010025, Oct 7, 2010

Feb 22, 2008

12/064673

Richard J. Melker - Gainesville FL, US
Donn Michael Dennis - Gainesville FL, US
Christopher D. Batich - Gainesville FL, US
Mark S. Gold - Alachua FL, US

G01N 33/50

436144

The present invention relates to the detection of markers in exhaled breath, wherein the detection of the presence or absence of the marker(s) in exhaled breath is used to assess various clinical data, including patient adherence in taking the medication and patient enzymatic (metabolic) competence in metabolizing the medication. An embodiment of the invention comprises a parent therapeutic agent labeled with a marker, where upon metabolism (e.g., via enzymatic action) of the therapeutic agent, the marker becomes volatile or semi-volatile and is present in the breath. In certain related embodiments, the marker contain a deuterium label, which is also present in the breath upon metabolism of the therapeutic agent. In another embodiment of the invention, the therapeutic agent is associated with a taggant (that may be either labeled or unlabeled with deuterium), which in turn will generate a marker in the breath that is easily measurable.

2006025, Nov 16, 2006

May 10, 2005

11/125937

David Bjoraker - Gainesville FL, US
Richard Melker - Gainesville FL, US
Donn Dennis - Gainesville FL, US

C12Q 1/68, G01N 33/92, G01N 33/00

435006000, 436071000, 436086000

Systems and methods for the diagnostic analysis of blood samples. The present invention uses sensor technology useful in the analysis of headspace sample from blood to provide an efficient and accurate means for identifying the presence of a volatile marker associated with hematological diseases or conditions. In a preferred embodiment, the sensor technology of the present invention includes detecting means such as RNA oligonucleotide chains or aptamers.

2013017, Jul 4, 2013

Dec 13, 2012

13/713666

Richard J. Melker - Gainesville FL, US
Donn M. Dennis - Gainesville FL, US

A61B 5/00, A61B 5/1455, A61B 5/02, A61B 5/113, A61B 5/01, A61B 5/0464, A61B 5/145, A61B 5/20, A61B 5/0476, A61B 5/0496, A61B 5/11, A61M 15/00, A61M 16/00, A61M 31/00, A61M 5/168, A61M 16/12, A61M 16/14, A61B 5/0205

600476

Provided according to embodiments of the present invention are methods of monitoring and treating respiratory depression that include securing a photoplethysmography (PPG) sensor to a central source site of an individual; administering a central nervous system (CNS) depressant to the individual; processing PPG signals front the PPG sensor with a computer in communication with the PPG sensor; and administering a narcotic reversal agent to the individual if the PPG signals or a physiological parameter derived therefrom are outside a preset value range. Related systems are also described.

6974706, Dec 13, 2005

Jan 16, 2003

10/345532

Richard J. Melker - Gainesville FL, US
Donn Michael Dennis - Gainesville FL, US

University of Florida Research Foundation, Inc. - Gainesville FL

G01N033/543

436518, 422 84, 435 6, 435 71, 435 79, 435 792, 436164, 436172, 436524, 436528, 436805, 436811, 436815, 436900

A method for detecting compounds of interest in bodily fluids, including exhaled breath and blood. The present invention uses biosensors that mimic naturally occurring cellular mechanisms, including RNA oligonucleotide chains or “aptamers,” in combination with molecular beacons or nanotechnology to provide an effective and efficient method for diagnosing a condition and/or disease within a patient. The subject invention also provides a method for screening those analytes/biomarkers likely to be present in exhaled breath.

8525666, Sep 3, 2013

Jun 9, 2008

12/599743

Richard J. Melker - Gainesville FL, US
Nikolaus Gravenstein - Gainesville FL, US
Donn Michael Dennis - Gainesville FL, US
Christopher Batich - Gainesville FL, US

University of Florida Research Foundation, Inc. - Gainesville FL

G08B 1/08

34053911, 340528, 3405731, 3405736, 34053912, 340632, 424 701

Systems and methods are provided for monitoring use of handwashing agents to determine compliance with hand hygiene guidelines. A handwashing agent is provided with a detectable, volatile compound, such as odors, which is then rubbed onto a subject's hands using the subject's handwashing technique. After the handwashing event, the subject's hand is then exposed to an detector (such as a badge), which includes a sensor capable of detecting the volatile compound, and an indicator that communicates detection of the volatile compound, indicating use of the handwashing agent and hand hygiene compliance.

2006016, Jul 20, 2006

Dec 7, 2005

11/296757

Richard Melker - Gainesville FL, US
Donn Dennis - Gainesville FL, US
Charles Martin - Gainesville FL, US
Jon Stewart - Gainesville FL, US

G01N 33/53

435007100

A method for detecting compounds of interest in bodily fluids, including exhaled breath and blood. The present invention uses biosensors that mimic naturally occurring cellular mechanisms, including RNA oligonucleotide chains or “aptamers,” in combination with signaling agents or nanotechnology to provide an effective and efficient method for diagnosing a condition and/or disease within a patient. The subject invention also provides a method for screening those analytes/biomarkers likely to be present in exhaled breath.

2010021, Aug 26, 2010

Aug 15, 2007

12/374564

Richard J. Melker - Gainesville FL, US
David G. Bjoraker - Gainesville FL, US
Donn Michael Dennis - Gainesville FL, US
Jon Dale Stewart - Gainesville FL, US
Christopher D. Batich - Gainesville FL, US
Matthew M. Booth - Gainesville FL, US
John Frederick Horn - Orange Park FL, US
Ronald Youngblood - Williston FL, US
Timothy E. Morey - Gainesville FL, US

C12Q 1/54, C12M 1/34, G01N 33/497, G01N 27/26

435 14, 422 84, 4352879, 436 95, 20440301, 20440314

Systems and methods for analyzing glucose present in exhaled breath condensate (EBC). In certain embodiments, electrochemical- or coulometnc-based sensing technologies are used to analyze EBC for the presence and/or concentration of glucose. Based on the detected glucose m EBC, the subject invention provides systems and methods for non-invasive, accurate assessment of blood glucose levels.

7978083, Jul 12, 2011

May 3, 2010

12/772583

Richard J. Melker - Gainesville FL, US
Nikolaus Gravenstein - Gainesville FL, US
Donn M. Dennis - Gainesville FL, US
Christopher D. Batich - Gainesville FL, US

University of Florida Research Foundation, Inc. - Gainesville FL

G08B 23/00

3405731, 3405736, 34053911, 34053912

Systems and methods are provided for monitoring use of hand washing agents to determine compliance with hand hygiene guidelines. A hand washing agent is provided with a detectable, volatile compound, such as odors, which is then rubbed onto a subject's hands using the subject's hand washing technique. After the hand washing event, the subject's hand is then exposed to an detector (such as a badge), which includes a sensor capable of detecting the volatile compound, and an indicator that communicates detection of the volatile compound, indicating use of the hand washing agent and hand hygiene compliance.