Inventors:
Robert E. Dempski - Dresher PA
Edward C. Scholtz - King of Prussia PA
Donald W. Nibbelink - Lansdale PA
Scott A. Reines - New Hope PA
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 922, A61K 926, A61K 3178
Abstract:
A matrix or monolithic drug delivery system for the controlled release of carbidopa and levodopa consists of the two drugs uniformly dispersed in a polymer vehicle at a concentration that is greater than the solubility of either drug in the polymer. Treatment of parkinsonism with the controlled release formulation provides several advantages over treatment with the standard carbidopa/levodopa combination presently employed.