Inventors:
Donald Small - Baltimore MD, US
Katharine A. Whartenby - Baltimore MD, US
Drew Pardoll - Brookeville MD, US
Assignee:
THE JOHN HOPKINS UNIVERSITY - Baltimore MD
International Classification:
A61K 31/7056, C12N 5/06, C12N 15/87, A01K 67/027, C12Q 1/02
US Classification:
514 43, 435375, 435455, 800 13, 435 29
Abstract:
New methods are provided for suppressing the immune system and for treating immune related disorders. Therapies of the invention include administration of an FLT3 inhibitor compound to a subject in need thereof, such as a subject suffering from organ rejection, bone marrow transplant rejection, acquired immune deficiency syndrome, arthritis, aplastic anemia, graft-versus-host disease, Graves' disease, established experimental allergic encephalitomyelitis, multiple sclerosis, lupus, or a neurological disorder. Methods are also provided for screening therapeutic agents for treating immune disorders, including the use of a mouse having an elevated level of FLT3 receptor activity.