Inventors:
Ai Lin - Potomac MD, US
Jian Guan - Olney MD, US
Quan Zhang - Rockville MD, US
Donald Skillman - Silver Spring MD, US
International Classification:
A61K 31/519, C07D 487/02
Abstract:
The invention relates to derivatives of pyrroloquinazolinediamine, more specifically derivatives of 7-(substituted)-7H-pyrrolo[3,2-F] quinazoline-1,3-diamines that are non-toxic and are also effective in the treatment of malaria, including and strains. The derivatives are certain carbamate derivatives, succinimide derivatives, alkylcarboxamides derivatives and acetamide derivative, phthalimides, alkylamines and all other amide and imide derivatives and their 1-hydroxy analogs. The derivatives of the present invention are also soluble in common organic solvents to facilitate the purification in a large scale synthesis of the composition.