DONALD LEE WISE
Engineers in Belmont, MA

6551355, Apr 22, 2003

Aug 14, 1998

09/133945

Kai-Uwe Lewandrowski - Brookline MA
Shrikar Bondre - Malden MA
Debra J. Trantolo - Princeton MA
Maurice V. Cattaneo - Quincy MA
Joseph D. Gresser - Brookline MA
Donald L. Wise - Belmont MA

Cambridge Scientific, Inc. - Cambridge MA

A61F 228

623 1611, 623 2363, 623 2375

A method by which immune responses to cortical bone grafts and other substrates (e. g. , cement, IPN, etc. ) can be minimized and at the same time graft osteoinductive potential can be improved, and improved graft substrate materials are disclosed. The method of the invention provides new types of bone grafts that incorporate into host bone more thoroughly and more rapidly, eliminating long-term complications, such as fracture, non-union, infection, and rejection. In the method of the invention, bone grafts or other substrates are modified to have an osteoinductive surface modification that the recipients body will accept as its own tissue type and therefore will not reject or otherwise cause to fail. The osteoinductive surface modification comprises a biopolymer matrix coating that is seeded with periosteal cells that have been previously harvested either from the graft recipient or from an allogenic or xenogenic donor source.

7077866, Jul 18, 2006

Feb 16, 2001

09/785593

Joseph D. Gresser - Brookline MA, US
Debra J. Trantolo - Princeton MA, US
Robert S. Langer - Newton MA, US
Kai-Uwe Lewandrowski - Brookline MA, US
Alexander M. Klibanov - Newton MA, US
Donald L. Wise - Belmont MA, US

DePuy Mitek, Inc. - Norwood MA

A61F 2/44

623 1716, 623 1711, 623 2375

A resorbable interbody fusion device for use in spinal fixation is disclosed. The device is composed of 25–100% bioresorbable or resorbable material. The interbody fusion device of the invention can be in any convenient form, such as a wedge, screw or cage. Preferably, the resorbable device of the invention is in the shape of a tapered wedge or cone, which further desirably incorporates structural features such as serrations or threads better to anchor the device in the adjoining vertebrae. The preferred device further comprises a plurality of peripheral voids and more desirably a central void space therein, which may desirably be filled with a grafting material for facilitating bony development and/or spinal fusion, such as an autologous grafting material. As the preferred material from which the resorbable interbody fusion device is manufactured is most likely to be a polymer that can produce acidic products upon hydrolytic degradation, the device preferably further includes a neutralization compound, or buffer, in sufficiently high concentration to decrease the rate of pH change as the device degrades, in order to prevent sterile abscess formation caused by the accumulation of unbuffered acidic products in the area of the implant.

5352423, Oct 4, 1994

Mar 30, 1993

8/039853

Yiannis A. Levendis - Boston MA
Donald L. Wise - Belmont MA

Northeastern University - Boston MA

B01D 5334

423235

A method is disclosed for removing pollutants from the exhaust of combustion systems burning fuels containing substantial amounts of sulfur and nitrogen. An exemplary method of the invention involves the formation and reaction of a sorbent comprising calcium benzoate. The calcium benzoate is either dry-sprayed (in the form of a fine powder) or wet-sprayed in an aqueous solution in a high temperature environment such as a combustion chamber. The latter technique is feasible since calcium benzoate is a water-soluble form of calcium. When the dispersed particles of calcium benzoate are heated to a high temperature, the organic benzoate burns off and fine calcium oxide particles are formed. These particles are cenospheric (hollow) and have thin and highly porous walls, thus, affording optimum external and internal accessibility for reacting with toxic gaseous emissions such as SO. sub. 2. Further, the combustion of the organic benzoate portion of the sorbent results in the conversion of NO. sub. x to N. sub. 2.

5456917, Oct 10, 1995

Jan 12, 1994

8/180914

Donald L. Wise - Belmont MA
Debra J. Trantolo - Princeton MA
Joseph D. Gresser - Brookline MA

Cambridge Scientific, Inc. - Belmont MA

A61K 4730

424426

A method for making an implantable bioerodible material for the sustained release of a medicament and the material made from the method. The method comprises the formulation of a biomaterial polymeric carrier into particles of predetermined density and size. The particles are then are mixed with the desired medicament and extruded into the desired shape for implantation or reground to a predetermined size distribution for injection as a suspension. In an alternative embodiment, the particles of polymeric carrier are immersed in a solvent containing a medicament, and the pores of the particles are filled with medicament through alternate application and release of vacuum.

6899107, May 31, 2005

Dec 27, 2002

10/330568

Kai-Uwe Lewandrowski - Brookline MA, US
Shrikar Bondre - Malden MA, US
Debra J. Trantolo - Princeton MA, US
Maurice V. Cattaneo - Quincy MA, US
Joseph D. Gresser - Brookline MA, US
Donald L. Wise - Belmont MA, US

Cambridge Scientific, Inc. - Boston MA

A61B019/00

128898, 623 1611, 623 66, 424426, 435325

A method by which immune responses to cortical bone grafts and other substrates (e. g. , cement, IPN, etc. ) can be minimized and at the same time graft osteoinductive potential can be improved, and improved graft substrate materials are disclosed. The method of the invention provides new types of bone grafts that incorporate into host bone more thoroughly and more rapidly, eliminating long-term complications, such as fracture, non-union, infection, and rejection. In the method of the invention, bone grafts or other substrates are modified to have an osteoinductive surface modification that the recipient's body will accept as its own tissue type and therefore will not reject or otherwise cause to fail. The osteoinductive surface modification comprises a biopolymer matrix coating that is seeded with periosteal cells that have been previously harvested either from the graft recipient or from an allogenic or xenogenic donor source.

4845034, Jul 4, 1989

Jan 6, 1986

6/816289

William M. Menger - Houston TX
Ernest E. Kern - Houston TX
Kermit Allen - Tulsa OK
O. C. Karkalits - Lake Charles LA
Donald L. Wise - Belmont MA
Alfred P. Leuschner - Ipswich MA

Houston Industries Incorporated - Houston TX

C12P 502

435167

A method for carrying out a biochemical reaction with a culture of microorganisms is performed in a cavity formed in a subterranean formation to produce combustible hydrocarbon gases. The method is especially suitable for the conversion of alkali-oxidized or hydrolyzed coal, such as lignite, to methane. The method may be performed in the cavity as a continuously stirred tank reaction, or plug flow or as a staged reaction. The method may also be done as an anaerobic fixed film process using particles as an anaerobic filter, as a sludge blanket, or as an expanded bed process.

6143534, Nov 7, 2000

Dec 24, 1991

7/814078

William M. Menger - Houston TX
Ernest E. Kern - Houston TX
O. C. Karkalits - Lake Charles LA
Donald L. Wise - Belmont MA
Alfred P. Leuschner - Cambridge MA
David Odelson - Cambridge MA
Hans E. Grethlein - Lansing MI

Reliant Energy Incorporated - Houston TX

C12P 502

435167

Lignite is treated with ligninase source to enhance its reactivity. In one embodiment, lignite is gasified in a subterranean reactor by simultaneous digestion by anaerobic ligninase producers, such as termite microflora, and acid formers and methanogens. In another embodiment, the lignite is treated with ligninase prior to digestion by the acid formers and methanogens. If desired, the lignite may be pretreated by alkaline hydrolysis.

5817328, Oct 6, 1998

Apr 3, 1996

8/626521

Joseph D. Gresser - Brookline MA
Debra J. Trantolo - Princeton MA
Robert Langer - Newton MA
Alexander M. Klibanov - Newton MA
Donald L. Wise - Belmont MA

Cambridge Scientific, Inc. - Belmont MA

A61F 202, A61K 4730, A61K 4732

424426

A bioerodible implantable material, comprising a bioerodible polymer that produces acidic products upon hydrolytic degradation, and a buffering compound that buffers the acidic products and maintains the local pH within a desired range. The buffer compound acts to reduce the inflammatory foreign body response generated by the acidic products and reduces the sterile abscess condition that occurs at the site of the bioerodible implant materials of the prior art. Materials made according to the invention may be used for internal fixation devices (IFDs) for bone repair.

6913760, Jul 5, 2005

Aug 6, 2002

10/213584

Daniel B. Carr - Chestnut Hill MA, US
Andrzej W. Lipkowski - Warsaw, PL
Donald L. Wise - Belmont MA, US
Vasif Hasirci - Ankara, TR

New England Medical Hospitals, Inc. - Boston MA

A61E013/00, A61E002/00, A61K009/14

424422, 424423, 424426, 424428, 424484, 424485, 424486

The invention provides a drug delivery compositions and methods for treating pain. A drug delivery composition contains a polymer and at least two drugs sucha as an analgesic agent and an anesthetic agent.

5094668, Mar 10, 1992

Nov 22, 1989

7/441355

Ernest E. Kern - Houston TX
William M. Menger - Houston TX
David A. Odelson - Mt. Pleasant MI
Anthony S. Sinskey - Cambridge MA
Donald L. Wise - Belmont MA
Debra J. Trantolo - Princeton MA

Houston Industries Incorporated - Houston TX

C10L 910, C10L 912

44622

Coal is desulfurized by oxidation to convert organic sulfur moieties in the coal matrix to sulfates, and by treatment with a sulfatase to cleave the sulfates and thereby remove organic sulfur.