DONALD LAWRENCE SIEGEL
Medical Practice in Lansdale, PA
License number
Pennsylvania MD044574E
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
Lansdale, PA 19446
Personal information
See more information about DONALD LAWRENCE SIEGEL at radaris.comName
Address
Phone
2582 Brandon Ct, Lansdale, PA 19446
2582 Brandon Ct, Worcester, PA 19490
2582 Brandon Ct, Lansdale, PA 19446
103 Marble Dr, Canonsburg, PA 15317
261 Maple St, Rillton, PA 15678
Professional information
Compositions, Methods And Kits For Detection Of An Antigen On A Cell And In A Biological Mixture
US Patent:
8617805, Dec 31, 2013
Filed:
Oct 22, 2004
Appl. No.:
10/971933
Inventors:
Donald L. Siegel - Lansdale PA, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
C12Q 1/70
US Classification:
435 5, 435 721, 435 725, 436520, 436521
Abstract:
The present invention relates to novel methods for detecting at least one member of a known binding pair in a sample, including a cell, where one member of the pair (termed the “receptor”) is expressed by a bacteriophage, which phage is then used to detect the presence of the other member of the pair (termed the “ligand” or “target”). Rather than detecting the binding of at least one phage using antibody-based technology, the present invention relates to detecting the nucleic acid associated with the phages. In one aspect, the invention relates to identifying at least one antigen-bearing moiety (e. g. , a red blood cell antigen) of interest present on a cell, e. g. , a red blood cell, using antibody-displaying bacteriophages, using antiglobulin reagent-displaying bacteriophages and detecting at least one nucleic acid associated with the phage.
Compositions, Methods And Kits For Detection Of An Antigen On A Cell And In A Biological Mixture
US Patent:
8586293, Nov 19, 2013
Filed:
Mar 8, 2005
Appl. No.:
11/074542
Inventors:
Donald L. Siegel - Lansdale PA, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
C12Q 1/70
US Classification:
435 5, 435 721, 435 725, 436520, 436521
Abstract:
The present invention relates to novel methods for detecting a member of a known binding pair in a sample, including a cell, where one member of the pair (termed the “receptor”) is expressed by a bacteriophage, which phage is then used to detect the presence of the other member of the pair (termed the “ligand” or “target”). Rather than detecting the binding of the phage using antibody-based technology, the present invention relates to detecting the nucleic acid associated with the phage. In one aspect, the invention relates to identifying an antigen-bearing moiety (e. g. , a red blood cell antigen) of interest present on a cell, e. g. , a red blood cell, using antibody-displaying bacteriophage, as well as detecting anti-red blood cell auto- or alloantibodies and/or complement in a sample, using antiglobulin reagent-displaying bacteriophage and detecting a nucleic acid associated with the phage.
Anti-Autoimmune Antibodies For Treatment Of Pemphigus
US Patent:
8298545, Oct 30, 2012
Filed:
Jan 25, 2008
Appl. No.:
12/525269
Inventors:
Aimee S. Payne - Merion Station PA, US
John R. Stanley - Gladwyne PA, US
Donald L. Siegel - Lansdale PA, US
John R. Stanley - Gladwyne PA, US
Donald L. Siegel - Lansdale PA, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
A61K 39/00
US Classification:
4241851
Abstract:
This invention relates to compositions and methods for the use of anti-autoimmune reagents that specifically bind to anti-desmoglein antibodies, which are responsible for both pemphigus vulgaris and pemphigus foliaceus. In addition, the invention relates to methods and compositions for inhibiting the expression or function of a variable region of an anti-desmoglein (anti-Dsg) pathogenic autoantibody.
Isolation Of Anti-Desmoglein 1 Antibodies By Phage Display Of Pemphigus Foliaceus Autoantibodies
US Patent:
2011009, Apr 21, 2011
Filed:
May 9, 2008
Appl. No.:
12/666265
Inventors:
Aimee S. Payne - Merion Station PA, US
John R. Stanley - Gladwyne PA, US
Donald L. Siegel - Lansdale PA, US
Ken Ishii - Tokyo, JP
John R. Stanley - Gladwyne PA, US
Donald L. Siegel - Lansdale PA, US
Ken Ishii - Tokyo, JP
International Classification:
A61K 39/395, C07K 16/18, C07K 16/42, C07K 2/00, C07H 21/00, C07H 21/02, A61K 38/02, A61K 31/7088, A61K 31/713, G01N 33/566, G01N 33/53, A61K 31/7105, A61P 17/00, A61P 29/00
US Classification:
4241311, 5303891, 5303873, 5303872, 530300, 536 2353, 536 245, 514 11, 514 187, 514 44 A, 514 44 R, 530322, 436501, 435 792
Abstract:
This invention relates to compositions and methods for the use of anti-autoimmune reagents that specifically bind to anti-desmoglein antibodies, which are responsible for pemphigus foliaceus. In addition, the invention relates to methods and compositions for inhibiting the expression or function of a variable region of an anti-desmoglein (anti-Dsg) pathogenic autoantibody.
Drug Delivery To Human Tissues By Single Chain Variable Region Antibody Fragments Cloned By Phage Display
US Patent:
8470323, Jun 25, 2013
Filed:
Jan 9, 2008
Appl. No.:
12/522526
Inventors:
John R. Stanley - Gladwyne PA, US
Donald L. Siegel - Lansdale PA, US
Amagai Masayuki - Tokyo, JP
Donald L. Siegel - Lansdale PA, US
Amagai Masayuki - Tokyo, JP
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
Keio University - Tokyo
Keio University - Tokyo
International Classification:
A61K 39/395
US Classification:
4241341
Abstract:
The present invention relates to the use of non-pathogenic antibodies to deliver biologically-active proteins to specific cellular and sub-cellular sites. The invention also relates to the use of non-pathogenic antibodies to deliver biologically-active, non-protein molecules to specific cellular and sub-cellular sites.
Compositions And Methods For Detection Of Antibody Binding To Cells
US Patent:
7709219, May 4, 2010
Filed:
Jan 9, 2006
Appl. No.:
11/328483
Inventors:
Donald L. Siegel - Lansdale PA, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
G01N 33/554, G01N 33/555
US Classification:
435 72, 435 721, 435 725, 436519, 436520
Abstract:
The invention includes Rh(D) binding proteins, including antibodies, and DNA encoding such proteins. Methods of generating such proteins and DNAs are also included.
Methods For Isolation Of Antibody Binding To Cells
US Patent:
8623594, Jan 7, 2014
Filed:
Mar 26, 2010
Appl. No.:
12/732979
Inventors:
Donald L. Siegel - Lansdale PA, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
G01N 33/53, G01N 33/567, A23J 1/00, C07K 1/00
US Classification:
435 5, 435 71, 435 721, 530412, 530413
Abstract:
The invention includes methods of isolating a multi-subunit protein which binds to an antigen-bearing moiety. The methods comprise generating a phage display library comprising a plurality of virus vectors.
Compositions, Methods And Kits Relating To Anti-Platelet Autoantibodies And Inhibitors Thereof
US Patent:
8216581, Jul 10, 2012
Filed:
Dec 23, 2004
Appl. No.:
11/021715
Inventors:
Donald L. Siegel - Lansdale PA, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
A61K 39/395, C07K 16/28, C07K 16/18
US Classification:
4241521, 4241331, 4241421, 4241431, 4241721, 424800, 424801, 424809, 5303873, 5303882, 53038822, 5303887, 53038815, 530866, 530867
Abstract:
The present invention relates to novel methods of identifying and producing an anti-platelet autoantibody. More preferably, the invention relates to identification and production of a human monoclonal anti-platelet autoantibody. Moreover, the invention relates to methods for treating or alleviating a disease, disorder or condition mediated by an anti-platelet autoantibody specifically binding with a platelet, or a component thereof, such as, but not limited to, idiopathic thrombocytopenic purpura, among others. Preferably, the antibody is an unglycosylated H44L4 Fab.
Anti-Tem1 Antibodies And Uses Thereof
US Patent:
2012029, Nov 22, 2012
Filed:
Nov 12, 2010
Appl. No.:
13/508925
Inventors:
Nathalie Scholler - Penn Valley PA, US
Aizhi Zhao - Rose Valley PA, US
Donald Siegel - Lansdale PA, US
George Coukos - Wynnewood PA, US
Aizhi Zhao - Rose Valley PA, US
Donald Siegel - Lansdale PA, US
George Coukos - Wynnewood PA, US
International Classification:
C07K 16/18, A61K 51/10, A61K 39/395, A61P 35/00, C12N 1/16, C12N 15/81, C40B 30/04, C40B 40/02, A61K 39/44, G01N 33/574
US Classification:
424 149, 5303879, 5303873, 4241781, 4241391, 435 723, 4352551, 435471, 506 9, 506 14, 4353201
Abstract:
The invention relates to Anti-TEM 1 anti-bodies or antigen-binding fragments thereof, yeast libraries comprising the same, and prophylactic, diagnostic, and therapeutic methods using the same.