Inventors:
Charles Zepp - Hardwick MA, US
Donald Heefner - Waynesboro PA, US
Paul Rubin - Sudbury MA, US
Mark Currie - Sterling MA, US
Assignee:
Sepracor, Inc. - Marlborough MA
International Classification:
A61K038/17
Abstract:
Ototoxic side-effects have either limited the application of an important group of antibiotics, aminoglycoside antibiotics, or have added further burden to those who have to resort to platinum-containing antineoplastic agents to treat life-threatening tumors. The present invention discloses pharmaceutical compositions that prevent or treat the ototoxic side-effects of aminoglycoside antibiotics and platinum-containing antineoplastic agents. The otoprotective compositions disclosed herein can also be used to treat noise induced hearing loss.