Dimitris Evangelos Nikitopoulos
Engineering at Towering Oaks Dr, Baton Rouge, LA
License number
Louisiana PE.0028253
Issued Date
Jan 26, 1999
Expiration Date
Mar 31, 2002
Category
Civil Engineer
Type
Mechanical Engineer
Address
Address
12007 Towering Oaks Dr, Baton Rouge, LA 70810
Professional information
Optimized Modular Microfluidic Devices
US Patent:
2009007, Mar 19, 2009
Filed:
Jun 30, 2008
Appl. No.:
12/164356
Inventors:
Michael C. Murphy - Baton Rouge LA, US
Dimitris E. Nikitopoulos - Baton Rouge LA, US
Steven A. Soper - Baton Rouge LA, US
Daniel S.-W. Park - Baton Rouge LA, US
Mateusz L. Hupert - Baton Rouge LA, US
Dimitris E. Nikitopoulos - Baton Rouge LA, US
Steven A. Soper - Baton Rouge LA, US
Daniel S.-W. Park - Baton Rouge LA, US
Mateusz L. Hupert - Baton Rouge LA, US
International Classification:
B01J 19/00
US Classification:
422206, 422240
Abstract:
Passively aligned modular microfluidic devices, and a method for fabricating such passively aligned polymeric modular microfluidic devices have been reported. The modular units fabricated are plurality of integrated microdevices. Also reported are microfluidic devices wherein isolated temperature zones exist so that the temperature within each zone may be distinctly and accurately controlled, and a method for fabricating such microfluidic devices wherein there are isolated temperature zones so that the temperature within each zone may be distinctly and accurately controlled. Such devices allow one to define constant temperature zones along a microfluidic channel where different reactions or stages of reactions occur.
Methods Of And Devices For Capturing Circulating Tumor Cells
US Patent:
2013010, May 2, 2013
Filed:
Oct 19, 2012
Appl. No.:
13/656295
Inventors:
Board of Supervisors of Louisiana State University - Baton Rouge LA, US
Daniel Sang-Won Park - Baton Rouge LA, US
Sudheer D. Rani - Baton Rouge LA, US
Michael C. Murphy - Baton Rouge LA, US
Dimitris E. Nikitopoulos - Baton Rouge LA, US
Daniel Sang-Won Park - Baton Rouge LA, US
Sudheer D. Rani - Baton Rouge LA, US
Michael C. Murphy - Baton Rouge LA, US
Dimitris E. Nikitopoulos - Baton Rouge LA, US
Assignee:
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College - Baton Rouge LA
International Classification:
C12M 1/26, C12Q 1/04, C12Q 1/68, C12Q 1/24, G01N 33/53
US Classification:
435 61, 4353091, 435 30, 435 71, 435 34
Abstract:
A device and methods are provided for efficient and quick capture of target cells through a main microchannel having capture elements immobilized thereon and manipulating a velocity profile of a sample as it passes through the main microchannel. The cell capture device may have a main microchannel with a depth slightly larger than the diameter of the target cells and a plurality of side microchannels. The side microchannels may have a depth smaller than the diameter of the target cells. The device and methods may be used for early cancer detection.
Electrokinetic Thermal Cycler And Reactor
US Patent:
2009015, Jun 18, 2009
Filed:
Oct 17, 2006
Appl. No.:
12/090396
Inventors:
Steven A. Soper - Baton Rouge LA, US
Dimitris E. Nikitopoulos - Baton Rouge LA, US
Michael C. Murphy - Baton Rouge LA, US
Dimitris E. Nikitopoulos - Baton Rouge LA, US
Michael C. Murphy - Baton Rouge LA, US
International Classification:
C12M 1/02, B01J 19/00, G01N 21/00
US Classification:
4352931, 422198, 422 681, 422 55
Abstract:
Microfluidic devices are disclosed for carrying out cyclic or iterated reactions such as PCR, LDR, and other cyclic or iterated reactions. A microchannel forms a closed loop, through which a reaction mixture may be thermally cycled an arbitrary number of times. Flow is preferably mediated primarily by electrokinetics. Multiple temperature zones may be employed along the course of a single microchannel loop, for example for PCR. Embodiments may be compact, automated, fast, and operable in continuous-flow mode. Real-time reaction monitoring may optionally be used.