Inventors:
Dilip J. Gole - Ann Arbor MI
R. Saul Levinson - Saline MI
James Carbone - Belleville MI
J. Desmond Davies - Grosse Pointe Farms MI
Assignee:
Janssen Pharmaceutica Inc. - Piscataway NJ
International Classification:
A61K 914
Abstract:
A method is disclosed for preparing pharmaceutical and other matrix systems that comprises solidifying a matrix composition dissolved or dispersed in a first solvent and subsequently contacting the solidified matrix with a second solvent that is substantially miscible with the first solvent at a temperature lower than the solidification point of the first solvent, the matrix components being substantially insoluble in the second solvent, whereby the first solvent is substantially removed resulting in a usable matrix.