DIARMAID HUGH DOUGLAS-HAMILTON
Pilots at Cabot St, Beverly Farms, MA

6675605, Jan 13, 2004

Oct 10, 2002

10/268299

Diarmaid H. Douglas-Hamilton - Beverly MA

Benbow Corporation - South Hamilton MA

F25B 308

624572, 62371

A container for storing and transporting semen, e. g. , equine semen, along with a corresponding method of packing the container, is provided. The container is formed of an insulated box and an insulated cover. The insulated box and insulated cover each includes a collection of ridges and recesses to create a friction fit between the two that will only work with the insulated cover being placed on the insulated box in a predetermined orientation. A cooling pack is disposed on a floor of the insulated box. An insert is disposed to rest on the cooling pack inside the insulated box, such that the cooling pack is beneath the insert when the insulated box is in an upright position. The insert has at least one chamber for receiving a storage capsule holding the semen sample. The insulated cover frictionally fits on the insulated box and makes contact with the insert to hold the insert in place. The insert makes sufficient contact with the cooling pack to enable conductive cooling of the semen sample in the insert, regardless of orientation of the container.

8422128, Apr 16, 2013

Nov 9, 2009

12/615036

Diarmaid H. Douglas-Hamilton - Beverly MA, US
Thomas G. Kenny - Ipswich MA, US

Hamilton-Thorne, Inc. - Beverly MA

G02B 21/06

359389, 607 89

A modular laser objective for use with a microscope is provided. A mounting modular body permits the modular objective to be releasably mounted to the turret of a microscope. The objective has an optical axis that permits an image beam to be emitted through the objective toward the eyepiece of a microscope. The modular body supports a mirror positioned at an angle to the optical axis of the objective. A modular laser assembly is mounted on the modular body on a first side of the mirror for directing a laser beam toward the mirror so that the energy is reflected off the mirror and through the objective in a direction that is substantially aligned with the optical axis of the objective. A modular indicator assembly is received in the modular body and includes a source of light positioned with the light incident on the other side of the mirror to reflect a beam of light in a direction opposite to the direction of the laser beam to provide an optical representation at the eyepiece of a microscope or on a camera of the position on the target of the laser beam being emitted by the objective.

4896966, Jan 30, 1990

Aug 15, 1986

6/897036

Paul Boisseau - Lexington MA
Diarmaid H. Douglas-Hamilton - Beverly MA
Thomas P. Sosnowski - Wayland MA

Hamilton-Thorn Research - Wenham MA

G01N 2100, G06K 900, C12M 134

356442

A motility scanner and method are disclosed for characterizing the motion of sperm, bacteria, particles suspended in flowing fluids and the like. The motility scanner preferably is mounted as a portable unit in a container and includes an optical system, a source of illumination for the system, a heated specimen support disposed in the system, ratiation sensing means coupled to the system, signal processing means for analyzing signals generated by the radiation sensing means, and a front panel disposed on the container and featuring an output screen, a printer and controls required for operating the motility detector, including a power switch. A disposable specimen holder of unique design allows external loading thereof and its positioning on the heated specimen support. The source of illumination can be a conventional filament lamp or one or more LED's. Power for the motility scanner can be self contained by incorporating a battery pack within the container or it can be derived from a conventional 110 V. A. C.

8149504, Apr 3, 2012

Jun 9, 2009

12/481363

Thomas G. Kenny - Ipswich MA, US
Diarmaid H. Douglas-Hamilton - Beverly MA, US

Hamilton Thorne Biosciences, Inc. - Beverly MA

G02B 21/06

359389, 607 89

An objective assembly for use with a microscope is provided. The objective has an optical axis that permits an image beam to be emitted through the objective toward the eyepiece of a microscope. A mirror is positioned at an angle to the optical axis of the objective. A laser assembly is positioned on a first side of the mirror for directing a laser beam toward said mirror so that the energy is reflected off the mirror and through the objective in a direction that is substantially aligned with the optical axis of the objective. An indicator assembly including a source of light is positioned with the light incident on the other side of the mirror to reflect a beam of light in a direction opposite to the direction of the laser beam to provide an optical representation at the eyepiece of a microscope of the position of the laser beam being emitted by the objective.

4530816, Jul 23, 1985

Jun 15, 1983

6/504578

Diarmaid H. Douglas-Hamilton - Beverly MA

Hamilton Farm - South Hamilton MA

F25D 308

422 1

A container for cooling, preserving and safely transporting a biological specimen includes a thermally insulating over-all container having as contents a container for ice, a container for the specimen including an isothermal metal cup, and a thermally insulating sheet interposed between the specimen container and the ice, the over-all container and the insulating sheet having thermal constants chosen to control the cooling rate, preferably to approximately one to three minutes per degree Centigrade, and to achieve a steady state temperature of the specimen near, but above freezing, preferably in the range of 4. degree. C. to 10. degree. C. The method of the invention includes the steps of packing biological specimens just after they are obtained into a specimen container and placing the specimen container near ice in an over-all insulating container, with a thermally insulating sheet between the ice and the specimen container, the thermal constants being chosen to cool down the specimen at an optimum cooling rate and to achieve an optimum steady state temperature for the specimen.

4896967, Jan 30, 1990

Mar 11, 1988

7/167682

Diarmaid H. Douglas-Hamilton - Beverly MA
Paul Boisseau - Waltham MA

Hamilton-Thorn Research - Danvers MA

G01N 2159, G01N 2145, G01N 33487

356442

An improved motility scanner is disclosed for characterizing the motion of sperm, bacteria, particles suspended in flowing fluids and the like. The motility scanner includes an improved optical system, a source of illumination for the system and radiation sensing means including electronic image reversal means coupled to the system. A disposable specimen holder allows external loading thereof and its positioning on a heated specimen support. The illumination source functions as a collimator in directing all of the emanating illumination onto the specimen. Both directly transmitted light and light scattered by the specimen are received by an imaging lens and are both focussed thereby onto pixels of a light sensitive device. A movable plate provided with a retarding member is designed to be located at the plane conjugate to the plane of the small source aperature. The directly transmitted light is transmitted through the retarding member and/or the attenuating member.

5306467, Apr 26, 1994

Feb 17, 1993

8/018734

Diarmaid H. Douglas-Hamilton - Beverly MA
Thomas Kenny - Woburn MA

Hamilton-Thorn Research - Beverly MA

B01L 300, B01L 900, G01N 2101

422 99

A magnetic slide loading is used with automated cell counting equipment or manual optical microscopes to measure the number of cells in a fluid biological sample. A slide having a defined volume region holds the sample for measurement. A cover slip is placed over the defined volume region creating an enclosed volume. An actuable holder clamp is placed over the slide securing it as well as the cover slip in position by virtue of magnets secured to the bottom of the device exerting a magnetic force upon the holder clamp such that it is attracted toward the slide forcing the cover slip to flatten, thereby removing any defects or distortions from the volume. This action ensures that the volume has a uniform depth allowing accurate measurement of cell concentration within the biological sample.

5093866, Mar 3, 1992

Feb 9, 1990

7/478205

Diarmaid H. Douglas-Hamilton - Beverly MA
Paul R. Loomis - Groveland MA
Paul Boisseau - Waltham MA
William P. Nett - Waltham MA

Hamilton Equine Associates Limited - Danvers MA
Laura Thorn Ltd. - Danvers MA

G06K 900

382 6

An apparatus and method for determining motility and other characteristics of cells in a fluid medium employing both the scattering and transmission of light through that medium and the absorption of shorter wavelength light by the cell with subsequent emission of fluorescent light. Both forms of light are imaged on an image detection apparatus, the output of which is analyzed as a function of time to produce the information concerning the characteristics of the cell.

7072377, Jul 4, 2006

Aug 5, 2003

10/635872

Diarmaid H. Douglas-Hamilton - Beverly MA, US

Hamilton Thorne BioSciences, Inc. - Beverly MA

G02B 21/06

372100, 359385, 374 6

A method for calculating and displaying the isothermal contours of the energy produced by a laser in a sample includes applying a laser beam to the focal point of a sample. The region near the focal point is divided into cylinders coaxial with the beam. The maximum temperature reached during the laser pulse of at least three points at arbitrary distances from the focal point is derived. The temperatures calculated are plotted as a function of distance from the focal point sufficient to generate isothermal contours. A computer display is then generated of the isothermal contours corresponding to the temperature calculations.

2011030, Dec 15, 2011

Jun 13, 2011

13/158843

Diarmaid H. Douglas-Hamilton - Beverly MA, US
Thomas G. Kenny - Ipswich MA, US

C12N 13/00, C12M 1/42

4351734, 4351731, 4352831

The present invention provides a method and system for using eye-safe infrared energy from a Class I laser to manipulate cells in culture. The laser energy produces one or more phase boundary propulsion events, which generate hydrodynamic forces sufficient to manipulate cells at the focal point.