Inventors:
Jason Eriksen - Houston TX, US
Dennis W. Dickson - Jacksonville FL, US
Matthew C. Baker - Jacksonville FL, US
Rosa Rademakers - Ponte Vedra Beach FL, US
Todd Robinson - Kirkland WA, US
International Classification:
C12Q 1/68
Abstract:
This document relates to methods and materials involved in detecting mutations linked to dementia (e.g., frontotemporal lobar degeneration). For example, methods and materials for determining whether or not a mammal is homozygous for a mutant T allele of rs5848 are provided. This document also relates to methods and materials involved in treating mammals having or being susceptible to developing neurodegenerative disorders (e.g., frontotemporal lobar degeneration). For example, methods and materials for inhibiting the ability of miRNA to suppress GRN polypeptide expression in mammals are provided.