Inventors:
David Harold Drewry - Durham NC, US
David Kendall Jung - Durham NC, US
James Andrew Linn - Durham NC, US
Robert Neil Hunter - Durham NC, US
Dennis Lee - King of Prussia PA, US
Robert A. Stavenger - King of Prussia PA, US
Clark Sehon - King of Prussia PA, US
International Classification:
A61K 31/4409, C07D 213/04, A61K 31/415, C07D 231/10, C07D 239/42, A61K 31/505, C07D 239/24, C07D 231/56, C07D 401/10
US Classification:
514256, 546337, 514357, 514406, 5483751, 544332, 514275, 544335, 544329, 5483625
Abstract:
There is provided compounds of Formula (I) and salts, solvates, and physiologically functional derivatives thereof:wherein R1 is hydrogen or Calkyl; n is 1, 2, 3 or 4; R2 is aryl, optionally substituted by one or two groups selected from the group consisting of halogen, hydroxy, cyano, Calkyl, Calkoxy, Calkanoyl, haloCalkyl, haloCalkoxy, aryl, aryloxy, Calkoxycarbonyl, Calkylsulfonyl and a group R3R4NSO(wherein R3 and R4 are independently hydrogen or Calkyl) and a 5- or 6-membered heteroaryl group; or n is 0 and R1 and R2, together with the nitrogen atom to which they are joined, form a 5- or 6-membered monocyclic heterocyclic ring or a 9- or 10-membered bicyclic heterocyclic ring wherein at least the ring which contains the nitrogen atom to which R1 and R2 are joined is non-aromatic, and wherein the 5- or 6-membered monocyclic heterocyclic ring or the 9- or 10-membered bicyclic heterocyclic ring is optionally substituted by one or two groups selected from the group consisting of halogen, hydroxy, cyano, oxo, Calkyl, Calkanoyl, Calkoxy, haloCalkyl, haloCalkoxy, aryl, aryloxy and Calkoxycarbonyl; and X is indazolyl, pyrazolyl or a group:wherein G is CH or N; and Yand Yare independently hydrogen, halogen and a group NR5R6 (wherein R5 and R6 are independently hydrogen, Calkyl or Calkenyl).