Inventors:
Frank Hallock Ebetino - Cincinnati OH
Susan Mary Kaas - Sherburne NY
Marion David Francis - Cincinnati OH
Dennis George Anthony Nelson - West Chester OH
John Michael Janusz - West Chester OH
Assignee:
The Procter & Gamble Company - Cincinnati OH
International Classification:
A61K 3140, A61K 31415, A61K 3142, A61K 31425
Abstract:
The present invention relates to quaternary nitrogen-containing phosphate compounds, and the pharmaceutically-acceptable salts and esters thereof having the general structure: ##STR1## wherein: Z is a saturated, unsaturated, or aromatic, monocyclic or polycyclic carbocycle or monocyclic or polycyclic heterocycle containing one or more heteroatoms selected from O, S, or N;
Y is N. sup. + (R. sup. 8). sub. 2 or C(R. sup. 1). sub. 2 and when Y is C(R. sup. 1). sub. 2, at least one R. sup. 2 must be N. sup. + (R. sup. 8). sub. 3 ;
R. sup. 1, R. sup. 2, R. sup. 5, and R. sup. 8 are defined in claim 1, m and n are integers from 0 to 10; m+n is from 0 to 10;
R is COOH; PO. sub. 3 H. sub. 2 ; SO. sub. 3 H; or P(O)(OH)R. sub. 4, wherein R. sub.