DR. DENNIS L. KASPER, M.D.
Medical Practice at Longwood Ave, Boston, MA
License number
Massachusetts 35699
Category
Medical Practice
Type
Research Study
Address
Address
181 Longwood Ave, Boston, MA 02115
Phone
(617) 365-8110
Personal information
See more information about DENNIS L. KASPER at radaris.comName
Address
Phone
75 Mill St APT 3A, Raynham, MA 02767
15 Hyslop Rd, Brookline, MA 02445
544 Ward St, Newton, MA 02459
48 Monument Ave, Charlestown, MA 02129
47 Harvard St, Charlestown, MA 02129
Organization information
See more information about DENNIS L. KASPER at bizstanding.comDennis L Kasper MD
77 Ave Louis Pasteur, Boston, MA 02115
Categories:
Neurology Physicians & Surgeons
Phone:
(617) 525-5300 (Phone)
Professional information
See more information about DENNIS L. KASPER at trustoria.com
Dr. Dennis L Kasper, Boston MA - MD (Doctor of Medicine)
Dr. Dennis L Kasper, Boston MA - MD (Doctor of Medicine)
Specialties:
Internal Medicine
Address:
BRIGHAM & WOMENS HOSPITAL
181 Longwood Ave, Boston 02115
(617) 525-0867 (Phone), (617) 525-0867 (Fax)
DEPARTMENT OF MICROBIOLOGY AND IMMUNOBIO
77 Avenue Louis Pasteur SUITE 1056C, Boston 02115
(617) 432-5505 (Phone)
181 Longwood Ave, Boston 02115
(617) 525-0867 (Phone), (617) 525-0867 (Fax)
DEPARTMENT OF MICROBIOLOGY AND IMMUNOBIO
77 Avenue Louis Pasteur SUITE 1056C, Boston 02115
(617) 432-5505 (Phone)
Certifications:
Internal Medicine, 1973
Awards:
Healthgrades Honor Roll
Languages:
English
Education:
Medical School
University of Illinois At Chicago / College of Medicine
Graduated: 1967
University of Illinois At Chicago / College of Medicine
Graduated: 1967
Dennis Kasper, Boston MA
Dennis Kasper, Boston MA
Work:
Channing Laboratory
181 Longwood Ave, Boston, MA 02115
181 Longwood Ave, Boston, MA 02115
Immunomodulating Polymers
Immunomodulating Polymers
US Patent:
7083777, Aug 1, 2006
Filed:
Mar 31, 2000
Appl. No.:
09/540024
Inventors:
Arthur O. Tzianabos - Reading MA, US
Dennis L. Kasper - Charlestown MA, US
Andrew B. Onderdonk - Westwood MA, US
Ying Wang - Brookline MA, US
Dennis L. Kasper - Charlestown MA, US
Andrew B. Onderdonk - Westwood MA, US
Ying Wang - Brookline MA, US
Assignee:
The Brigham and Women's Hospital, Inc. - Boston MA
International Classification:
A61K 38/16, A61K 38/20
US Classification:
424 9322, 4241921, 530300, 530350, 5303783, 530 33, 530402, 514 2
Abstract:
A pharmaceutical composition consisting of identical repeating units, each unit having a charge motif composed of a positively charged free amino moiety and a negatively charged moiety, wherein the positively charged free amino moiety and the negatively charged moiety of each charge motif are separated by at least one neutral amino acid, and wherein the positively charged free amino moiety of one of the charge motifs is separated by a distance of at least 8 amino acids from the positively charged amino moiety of another charge motif, and a pharmaceutically acceptable carrier. Said pharmaceutical composition is useful for inducing IL-2, activating T cells to produce a T helper 1 cytokine profile, suppressing IgG antibody response to specific antigen, promoting allograft survival, reducing postoperative surgical adhesion formation, and/or protecting against abscess formation associated with surgery, trauma or diseases that predispose the host to abscess formation.
Immunomodulating Polymers
Immunomodulating Polymers
US Patent:
2004020, Oct 21, 2004
Filed:
May 19, 2004
Appl. No.:
10/848779
Inventors:
Arthur Tzianabos - Reading MA, US
Dennis Kasper - Charlestown MA, US
Andrew Onderdonk - Westwood MA, US
Ying Wang - Brookline MA, US
Dennis Kasper - Charlestown MA, US
Andrew Onderdonk - Westwood MA, US
Ying Wang - Brookline MA, US
Assignee:
The Brigham and Women's Hospital, Inc. - Boston MA
International Classification:
A61K038/17
US Classification:
514/012000
Abstract:
Methods and products for inducing IL-2 secretion, inducing IL-10 secretion, activating T cells, suppressing IgG antibody response to specific antigen, promoting allograft survival, reducing postoperative surgical adhesion formation, and protecting against abscess formation associated with surgery, trauma or diseases that predispose the host to abscess formation are provided. The methods of the invention are accomplished using an immunomodulator which is a polymer having at least two repeating charge motifs separated by at least a certain minimum distance.
Zwitterionic Immunomodulators For The Treatment Of Asthma And Allergy
Zwitterionic Immunomodulators For The Treatment Of Asthma And Allergy
US Patent:
2004021, Nov 4, 2004
Filed:
Mar 31, 2004
Appl. No.:
10/814620
Inventors:
Arthur Tzianabos - Reading MA, US
Dennis Kasper - Charlestown MA, US
Dennis Kasper - Charlestown MA, US
Assignee:
The Brigham and Women's Hospital, Inc. - Boston MA
International Classification:
C12Q001/68, A61K039/00, A61K039/38
US Classification:
424/184100
Abstract:
Methods and products for treating and protecting against asthma and allergic conditions are provided. The methods and products are related to certain naturally occurring and synthetic zwitterionic polymers which are found to induce certain T regulatory (Treg) cells and to exert immunosuppressive effects in vitro and in vivo.
Live Attenuated Vaccine Strain For Prevention Of Tularemia
Live Attenuated Vaccine Strain For Prevention Of Tularemia
US Patent:
2010030, Dec 2, 2010
Filed:
Sep 22, 2006
Appl. No.:
11/992429
Inventors:
Arthur O. Tzianabos - Reading MA, US
Dennis L. Kasper - Charlestown MA, US
Shite Sebastian - Malden MA, US
Eric Rubin - Waban MA, US
Simon T. Dillon - Danvers MA, US
Dennis L. Kasper - Charlestown MA, US
Shite Sebastian - Malden MA, US
Eric Rubin - Waban MA, US
Simon T. Dillon - Danvers MA, US
Assignee:
President and Fellows of Harvard College - Cambridge MA
International Classification:
A61K 39/02, A61P 31/04, C12N 15/74, C12Q 1/02, G01N 33/53, C12Q 1/68
US Classification:
4242341, 435471, 435 29, 435 76, 435 6
Abstract:
The invention provides live attenuated avirulent strains of as well as methods for their preparation and use in protecting a mammal against infection with and against tularemia.
Generation Of Psa-Only Producing Mutant Strain
Generation Of Psa-Only Producing Mutant Strain
US Patent:
2013012, May 16, 2013
Filed:
Oct 3, 2012
Appl. No.:
13/573695
Inventors:
Sarkis K. Mazmanian - Porter Ranch CA, US
Sung-Eun Lee - Los Angeles CA, US
Dennis L. Kasper - Charlestown MA, US
Sung-Eun Lee - Los Angeles CA, US
Dennis L. Kasper - Charlestown MA, US
Assignee:
The Brigham and Women's Hospital, Inc. - Boston MA
California Institute of Technology - Pasadena CA
California Institute of Technology - Pasadena CA
International Classification:
C12N 15/74
US Classification:
424 932, 4352523, 5361231, 424780
Abstract:
Provided is an isolated bacterial cell producing a native capsular polysaccharide A (PSA), wherein the cell is incapable of producing capsular polysaccharides PSB, PSC, PSD, PSE, PSF, PSG, and PSH because the cell's biosynthetic genes for native capsular polysaccharides PSB, PSC, PSD, PSE, PSF, PSG, and PSH have been deleted from the cell's genome. The isolated isolated or wild type , or an extract obtained from said cell, can be used to treat individuals with inflammation.
Method For Overexpression Of Zwitterionic Polysaccharides
Method For Overexpression Of Zwitterionic Polysaccharides
US Patent:
7678558, Mar 16, 2010
Filed:
Jan 17, 2007
Appl. No.:
11/654246
Inventors:
Laurie E. Comstock - Medfield MA, US
Katja G. Weinacht - Denzlingen, DE
Michael J. Coyne - North Attleboro MA, US
Dennis L. Kasper - Charlestown MA, US
Arthur O. Tzianabos - Reading MA, US
Katja G. Weinacht - Denzlingen, DE
Michael J. Coyne - North Attleboro MA, US
Dennis L. Kasper - Charlestown MA, US
Arthur O. Tzianabos - Reading MA, US
Assignee:
The Brigham and Women's Hospital, Inc. - Boston MA
International Classification:
C12N 1/12, C12P 21/06, C12P 19/34, C12P 19/04, C12N 1/20, A01N 63/00, C07H 21/04
US Classification:
4352521, 4352523, 435 691, 435 911, 435101, 435183, 435221, 4352525, 4353201, 435471, 435476, 435477, 435490, 424 9346, 424 932, 424 931, 436 232
Abstract:
The present invention is directed to methods for producing and selecting novel mutant strains of that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; compositions directed to the novel mutant strains of that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; improved methods for purification of individual capsular polysaccharides; and compositions directed to novel res02 and inv19 genes and their gene products. Significantly, the present invention provides methods and compositions for overexpressing and purifying immunomodulatory capsular polysaccharide A (PSA) in high yield.
Method For Overexpression Of Zwitterionic Polysaccharides
Method For Overexpression Of Zwitterionic Polysaccharides
US Patent:
7166455, Jan 23, 2007
Filed:
Mar 13, 2003
Appl. No.:
10/388390
Inventors:
Laurie E. Comstock - Medfield MA, US
Michael J. Coyne - North Attleboro MA, US
Dennis L. Kasper - Charlestown MA, US
Arthur O. Tzianabos - Reading MA, US
Katja G. Weinacht - Denzlingen, DE
Michael J. Coyne - North Attleboro MA, US
Dennis L. Kasper - Charlestown MA, US
Arthur O. Tzianabos - Reading MA, US
Katja G. Weinacht - Denzlingen, DE
Assignee:
The Brigham and Women's Hospital, Inc. - Boston MA
International Classification:
C12N 1/12, C12N 1/20, C12P 21/06, C12P 19/04
US Classification:
4352521, 4352523, 435 691, 435101
Abstract:
The present invention is directed to methods for producing and selecting novel mutant strains of that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; compositions directed to the novel mutant strains of that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; improved methods for purification of individual capsular polysaccharides; and compositions directed to novel res02 and inv19 genes and their gene products. Significantly, the present invention provides methods and compositions for overexpressing and purifying immunomodulatory capsular polysaccharide A (PSA) in high yield.
Modified Streptococcal Polysaccharides And Uses Thereof
Modified Streptococcal Polysaccharides And Uses Thereof
US Patent:
7858101, Dec 28, 2010
Filed:
Nov 1, 2005
Appl. No.:
11/264731
Inventors:
Dennis L. Kasper - Charlestown MA, US
Hilde-Kari Guttormsen - Brookline MA, US
Hilde-Kari Guttormsen - Brookline MA, US
Assignee:
The Brigham and Women's Hospital, Inc. - Boston MA
International Classification:
A61K 39/09, A61K 39/02, A61K 39/116, A61K 39/385, A61K 39/00, A61K 31/70, C07H 1/00
US Classification:
4242441, 4242341, 42419711, 4242031, 4241841, 4241941, 424831, 514 23, 5361231
Abstract:
Modified streptococcal polysaccharides and methods of using the modified polysaccharides are provided herein.