Dennis Joseph Hlavinka
Massage Therapy at Salvia Ct, Arvada, CO

2002013, Sep 26, 2002

Mar 21, 2002

10/104766

Keith Manica - Lakewood CO, US
Dennis Hlavinka - Arvada CO, US
Jeannie Woods - Arvada CO, US

Gambro, Inc.

A61B019/00, A61M037/00, B65D035/22

604/410000, 604/006150, 604/522000, 222/094000

A container for pathogen inactivating and storing blood or blood components, which includes multiple sub-compartments fluidly interconnected by an openable closure assembly. Each sub-compartment may contain a component necessary for pathogen inactivation or blood storage. Upon opening the openable closure assembly, the sub-compartments become one compartment and the components contained within each sub-compartment may be mixed together to form a combined solution for pathogen inactivation and/or storage of blood or blood components.

7582049, Sep 1, 2009

Feb 8, 2006

11/307451

Dennis J. Hlavinka - Arvada CO, US
William G Palsulich - Lakewood CO, US
Thomas J. Felt - Boulder CO, US
Frank Corbin, III - Littleton CO, US

CaridianBCT, Inc. - Lakewood CO

B04B 5/02

494 16, 417475, 4174771, 494 31, 494 33, 494 56

A centrifugal fluid separation system is disclosed for centrifugally separating a composite fluid into components thereof. This centrifugal separation system includes at least a centrifugal rotor which has a composite fluid containment area, a fluid flow channel/tubing and at least one separated component collection area defined therein. A composite fluid to be separated is delivered to the fluid containment area where under centrifugal forces the composite fluid is separated into components and then from which a component travels through an outlet channel to a respective separated component fluids flowing therethrough. A centrally disposed pump is also provided to move the separated component(s) to the collection area(s). Optical sensing of the interface of the separated fluid components may be used with a clamp to stop flow. A disposable bag and tubing system is also disclosed for use with reusable rotor devices.

5876321, Mar 2, 1999

Jun 9, 1997

8/871244

Dennis Hlavinka - Arvada CO
Thomas J. Felt - Boulder CO

Cobe Laboratories, Inc. - Lakewood CO

B04B 1104

494 10

A centrifuge apparatus is used for collecting white blood cells (WBC), primarily mononuclear cells, from whole blood stratified into layers. A thin mononuclear (MNC) layer is formed at the interface of red blood cells and plasma. A barrier is positioned in the separation vessel of the centrifuge at a location to intercept the thin layer. MNC fluid is allowed to pool behind the barrier before collection is started. To collect the MNC pool, the stratified red blood cell layer is raised from below the interface level by slowing or reversing flow in the RBC exit line thereby causing the MNC pool to spill over the barrier into a well in which a collect line is positioned. Collection ceases when a desired percentage of the pool is removed and the normal position of the interface is re-established; thereafter the pool builds again. By raising the MNC pool from below, improvements in purity and collect volume are achieved. The collection procedure can be useful for harvesting granulocytes and, in general, any sparse stratified component of a centrifuged solution where the sparse component is layered between more dense and less dense strata.

7549956, Jun 23, 2009

Feb 7, 2006

11/348524

Dennis Hlavinka - Arvada CO, US
Thomas J. Felt - Boulder CO, US

Caridianbct, Inc. - Lakewood CO

B04B 11/00

494 37, 494 45

An apparatus and method are provided for separating components of a fluid or particles. A separation vessel having a barrier dam is provided to initially separate an intermediate density components of a fluid, and a fluid chamber is provided to further separate these intermediate density components by forming an elutriative field or saturated fluidized particle bed. The separation vessel includes a shield for limiting flow into the fluid chamber of relatively high density substances, such as red blood cells. The separation vessel also includes a trap dam with a smooth, gradually sloped downstream section for reducing mixing of substances. Structure is also provided for adding additional plasma to platelets and plasma flowing from the fluid chamber. The system reduces clumping of platelets by limiting contact between the platelets and walls of the separation vessel.

6843961, Jan 18, 2005

Feb 3, 2003

10/357599

Dennis J. Hlavinka - Arvada CO, US
Raymond P. Goodrich - Lakewood CO, US
Laura Goodrich - Lakewood CO, US
Daniel McGraw - Riverton UT, US

Gambro, Inc. - Lakewood CO

A61L 200, B01J 1900, C12N 1300, C12N 100, C12N 900

422 24, 422 1, 422 22, 422 28, 422 40, 422 44, 422292, 422307, 435448, 4351731, 435183, 435184, 435236, 435243, 435244

Methods and apparatuses are provided for inactivation of pathogens in fluids containing blood products. Preferred methods include the steps of adding an effective, nontoxic amount of a photosensitizer such as riboflavin to the blood product and exposing the fluid to light having a peak wavelength.

2003014, Jul 31, 2003

Dec 23, 2002

10/328717

Frank Corbin - Littleton CO, US
Dennis Hlavinka - Arvada CO, US
Laura Goodrich - Lakewood CO, US
Raymond Goodrich - Lakewood CO, US

A61L002/08

210/748000, 210/758000, 210/764000, 422/022000, 422/029000

Methods for decontaminating fluids such as blood products, particularly platelets or red blood cells, are provided. The methods include mixing substantially non-toxic amounts of an endogenous photosensitizer such as riboflavin, or an endogenously-based derivative photosensitizer, with the fluid, increasing the dissolved oxygen content of the fluid to an amount sufficient to enhance a reaction of the photosensitizer in which singlet oxygen is formed and reduce competing reactions; and exposing the fluid to visible light photoradiation to activate the photosensitizer and substantially inactivate the pathogens. Blood products produced by the method, and systems for carrying out the method are also provided.

7438679, Oct 21, 2008

Dec 17, 2007

11/957946

Dennis J. Hlavinka - Arvada CO, US
Eric T. Hansen - Thornton CO, US

CaridianBCT Biotechnologies, LLC - Lakewood CO

B04B 9/14

494 82, 494 16, 494 30, 494 37

Apparatus and method for balancing a centrifuge having interconnected hydraulic chambers in containers on a rotor, each container being adapted to receive a composite fluid, comprising transferring, by the rotation of the rotor, hydraulic liquid from a source to the interconnected hydraulic chambers to balance the centrifuge.

2008017, Jul 24, 2008

Aug 17, 2007

11/840759

Dennis J. HLAVINKA - Arvada CO, US
Raymond P. GOODRICH - Lakewood CO, US
Heather REDDY - Denver CO, US

NAVIGANT BIOTECHNOLOGIES, LLC - Lakewood CO

A01N 1/02, C12M 1/00

435 2, 4353061

Methods and apparatuses are provided for reduction of pathogens in fluids containing blood products. Preferred methods include the steps of adding an effective, non-toxic amount of a photosensitizer such as riboflavin to the blood product and exposing the fluid to light having a peak wavelength.

6053856, Apr 25, 2000

May 8, 1997

8/853374

Dennis Hlavinka - Arvada CO

Cobe Laboratories - Lakewood CO

B01D 2126, B04B 708

494 37

An apparatus and method are provided for separating components of a fluid or particles. A separation vessel having a barrier dam is provided to initially separate an intermediate density components of a fluid, and a fluid chamber is provided to further separate these the intermediate density component by forming an elutriative field or saturated fluidized particle bed. The separation vessel is placed in a retainer on a centrifuge rotor and ridges in the retainer form various dams in the separation vessel. Also discloses are tubing sets and various separation vessels for use with the apparatus.

2008023, Sep 25, 2008

Mar 20, 2007

11/688694

Dennis J. Hlavinka - Arvada CO, US

GAMBRO BCT INC. - Lakewood CO

G01N 21/51, A61M 37/00

604 608, 250432 R

The present invention is related to pre-connected disposable sets including a pre-connected bag containing a photosensitizer for use in a blood separation and pathogen inactivation procedure.