Inventors:
Deborah Dean - Oakland CA, US
Assignee:
Children's Hospital & Research Center at Oakland - Oakland CA
International Classification:
A61K 39/00, A61K 39/02, C07K 1/00, C07K 2/00
US Classification:
4241851, 4241901, 4241921, 4242341, 530300, 530350
Abstract:
The present invention provides a method of classifying an epitope displayed by a polypeptide; a method of determining the presence of an epitope on a polypeptide encoded by a test nucleotide sequence; and a method of generating a nucleotide sequence encoding a polypeptide that exhibits a selected epitope. The present invention provides antigenic polypeptides that display selected epitope(s); chimeric macromolecules comprising such polypeptides; and compositions comprising the antigenic polypeptides or chimeric macromolecules. The present invention further provides methods of inducing an immune response to a. The present invention further provides arrays of nucleic acids, arrays of polypeptides, and arrays of antibodies, which arrays are useful in identification and/or classification of a.