Inventors:
Bela Rajiv Patel - King of Prussia PA, US
Deborah Smith - Durham NC, US
Debra J. Tompson - King of prussia PA, US
Parnian Zia-Amirhosseini - Thousand Oaks CA, US
Assignee:
SmithKline Beecham Corporation - Philadelphia PA
International Classification:
A61K 39/395
Abstract:
The present invention relates generally to the methods for the treatment and diagnosis of conditions mediated by IL-5 and excess eosinophil production, and more specifically to mAbs, Fabs, chimeric and humanized antibodies. More particularly, methods are provided for reducing eosinophils in a human in need thereof, which method comprises administering to said human a composition comprising at least one anti-IL-5 antibody, wherein at least one anti-IL-5 antibody provides a mean maximum plasma concentration of said anti-IL-5 antibody of at least about 1.03±0.21 μg/mL, an Area Under the Curve value of at least about 15.5±2.7 μg/day/mL and a serum half-life of about 16.2±2.1 days to about 21.7±2.8 days.