Inventors:
Dean Li - Salt Lake City UT, US
Christopher Jones - Salt Lake City UT, US
Nyall London - Bountiful UT, US
Assignee:
University of Utah Research Foundation - Salt Lake City UT
International Classification:
A61K 38/16, A61K 38/17, C07K 14/435
US Classification:
514 133, 514 212, 514 11, 530350
Abstract:
Compounds, compositions and methods for inhibiting vascular permeability and pathologic angiogenesis are described herein. Methods for producing and screening compounds and compositions capable of inhibiting vascular permeability and pathologic angiogenesis are also described herein. Pharmaceutical compositions are included in the compositions described herein. The compositions described herein are useful in, for example, methods of inhibiting vascular permeability and pathologic angiogenesis, including methods of inhibiting vascular permeability and pathologic angiogenesis induced by specific angiogenic, permeability and inflammatory factors, such as, for example VEGF, bFGF and thrombin. Methods for treating specific diseases and conditions are also provided herein.