Inventors:
Hong Liu - San Diego CA, US
Arnab Chatterjee - Encinitas CA, US
David Tully - San Diego CA, US
Phillip Alper - Poway CA, US
Badry Bursulaya - San Diego CA, US
Jianhua Guo - San Diego CA, US
David Woodmansee - San Diego CA, US
Daniel Mutnick - San Diego CA, US
Donald Karanewsky - Escondido CA, US
Yun He - San Diego CA, US
International Classification:
A61K031/54, A61K031/537, A61K031/495, A61K031/445, A61K031/401, A61K031/397
US Classification:
514210170, 514227500, 514237500, 514255010, 514317000, 514419000, 514423000, 544059000, 544162000, 544386000, 546226000, 548492000, 548537000, 548953000
Abstract:
The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.