Inventors:
Yi Zheng - Cincinnati OH, US
Huzoor Akbar - Athens OH, US
David A. Williams - Cincinnati OH, US
Wieslaw Adam Mazur - Mason OH, US
Assignee:
Cincinnati Children's Hospital Medical Center - Cincinnati OH
International Classification:
A61K 31/506
Abstract:
The preferred embodiments generally relate to methods and compositions that affect the GTP-binding activity of members of the Rho family GTPases, preferably Rac (Rac1, Rac2 and/or Rac3), such compositions include compounds that modulate the GTP/GDP exchange activity, along with uses for the compounds including screening for compounds which recognize Rac GTPase, and methods of treating pathological conditions associated or related to a Rho family GTPase, including Rac. The preferred embodiments also relate to methods of using such compounds, or derivatives thereof, e. g. , in therapeutics, diagnostics, and as research tools.