Inventors:
Kenneth H. Eckels - Rockville MD
Joseph R. Putnak - Silver Spring MD
Doria R. Dubois - Wheaton MD
Bruce L. Innis - Haverford PA
Charles H. Hoke - Columbia MD
David Vaughn - Silver Spring MD
Niranian Kanesa-thasan - Rockville MD
Assignee:
The United States of America as represented by the Secretary of the Army - Washington DC
International Classification:
A61K 39193
Abstract:
The present invention provides vaccine compositions of attenuated dengue-2 virus. More specifically, the attenuated virus is produced by serial passage in PDK cells. The invention also provides methods for stimulating the immune system of an individual to induce protection against dengue-2 virus by administration of attenuated dengue-2 virus.