Inventors:
Jonathan S. Stamler - Chapel Hill NC, US
David S. Warner - Durham NC, US
James D. Reynolds - Durham NC, US
Huaxin Sheng - Durham NC, US
Assignee:
Duke University - Durham NC
International Classification:
A61K 33/26, A61K 31/04, A61K 33/00, A61K 31/198, A61P 7/04
US Classification:
424646, 514740, 424718, 514562
Abstract:
A method for attenuating vasoconstriction in a patient with subarachnoid hemorrhage by administering to the patient a therapeutically effective amount of a compound which mediates an increase of bioactive nitric oxide in blood or tissue in the subarachnoid space to cause vasodilation in cerebral, carotid and basilar arteries after the administration of the compound, and wherein the administration of the compound does not reduce mean arterial blood pressure by more than 10%.