DAVID W GORDON
Landscape Architect in Gardenville, PA
License number
Pennsylvania LA000146L
Category
Landscape Architects
Type
Landscape Architect
Address
Address
Gardenville, PA 18901
Professional information
11Βhydroxysteroid Dehydrogenase Type 1
US Patent:
8420365, Apr 16, 2013
Filed:
Oct 8, 2008
Appl. No.:
12/681916
Inventors:
David Gordon - Doylestown PA, US
Yuval Blat - Wynnewood PA, US
Akbar Nayeem - Newtown PA, US
Mark S. Kirby - New Hope PA, US
Bin He - Plainsboro NJ, US
Yuval Blat - Wynnewood PA, US
Akbar Nayeem - Newtown PA, US
Mark S. Kirby - New Hope PA, US
Bin He - Plainsboro NJ, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C12N 9/02
US Classification:
435189, 435183, 530350
Abstract:
The invention provides gene-targeted non-human animals comprising a genetically modified 11βHSD1 gene encodes a mutant 11βHSD1 polypeptide which is modulated by human 11βHSD1 modulating compounds. The invention further provides cells expressing mutant 11βHSD1 and cells isolated from gene-targeted animals, which cells produce a mutant 11βHSD1. The invention further provides methods of identifying agents that modulate 11βHSD1 activity, and are useful to treat 11βHSD1-related metabolic disorders.