Inventors:
Matthew Moyle - Escondido CA
David L. Foster - San Diego CA
George P. Vlasuk - Carlsbad CA
Assignee:
Corvas International, Inc. - San Diego CA
International Classification:
C07H 2104
US Classification:
435 691, 435320, 435325, 435358, 536 231, 536 241, 530300, 530324, 530326, 530328, 530350
Abstract:
Compositions enriched for Neutrophil Inhibitory Factor which inhibit neutrophil activity including adhesion to vascular endothelial cells are provided. Such compositions may comprise a glycoprotein isolated from nematodes. These compositions are useful in the therapy of conditions which involve abnormal or undesired inflammatory responses.